{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:42:45Z","timestamp":1777488165238,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T00:00:00Z","timestamp":1496016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Adhesion after pelvic surgery causes infertility, ectopic pregnancy, and ileus or abdominal pain. The materials currently available for clinical use are insufficient. The purpose of this study was to develop an anti\u2010adhesive material that overcomes the limitations of conventional anti\u2010adhesive agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The adhesion prevention effects of three methods \u2013 a two\u2010layered sheet composed of gelatin film and gelatin sponge, Seprafilm and INTERCEED \u2013 were evaluated in 37 dogs. Anti\u2010adhesive effects were investigated macroscopically and microscopically in a cauterized uterus adhesion model. Cell growth on the materials <jats:italic>in vitro<\/jats:italic> using human peritoneal mesothelial cells, fibroblasts and uterine smooth muscle cells were also evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The two\u2010layered gelatin sheet had significantly superior anti\u2010adhesive effects compared to the conventional materials (Seprafilm and INTERCEED). A single\u2010cell layer of mature mesothelium formed three weeks after surgery in the gelatin group. Peritoneum regeneration in the Seprafilm and INTERCEED groups was delayed and incomplete in the early phase. Little inflammation around the materials occurred and cell growth was significantly proliferated with the gelatin sheet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The anti\u2010adhesive effects of a two\u2010layered gelatin sheet were superior to conventional agents in a cauterized canine uterus model, demonstrating early regeneration of the peritoneum, little inflammation and material endurance. The newly developed two\u2010layered gelatin sheet is a useful option as an anti\u2010adhesive agent for deeply injured and hemorrhagic sites.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13358","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T13:26:42Z","timestamp":1496064402000},"page":"1317-1325","source":"Crossref","is-referenced-by-count":9,"title":["Anti\u2010adhesive effects of a newly developed two\u2010layered gelatin sheet in dogs"],"prefix":"10.1111","volume":"43","author":[{"given":"Hiroko","family":"Torii","sequence":"first","affiliation":[{"name":"Kusatsu General Hospital  Kusatu Shiga Japan"},{"name":"Department of Life and Medical Science, Division of Medical Life System Doshisha University  Kyotanabe Kyoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitaka","family":"Takagi","sequence":"additional","affiliation":[{"name":"Department of Life and Medical Science, Division of Medical Life System Doshisha 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