{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T17:30:53Z","timestamp":1773163853121,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our aim was to investigate the effects of angiogenesis\u2010related factor levels at 19\u201325 and 26\u201331\u00a0weeks of gestation (WG) on the later occurrence of a small\u2010for\u2010gestational\u2010age (SGA) placenta (small placenta) or an SGA infant delivered at 35\u201341\u00a0WG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured plasma levels of soluble fms\u2010like tyrosine kinase 1 (sFlt\u20101) and placental growth factor (PlGF), and the serum level of soluble endoglin (sEng) in 679 pregnant women with blood sampling at both 19\u201325 and 26\u201331\u00a0WG in a prospective study. A small placenta and an SGA infant were defined as &lt;10th percentile, respectively. Multivariate logistic regression analyses were performed using maternal factors, a high mean pulsatility index (high mPI) of the uterine artery in the second trimester, and angiogenesis\u2010related factor levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regarding the occurrence of a small placenta, low PlGF at 19\u201325\u00a0WG (adjusted odds ratio [95% confidence interval]: 2.4 [1.01\u20135.7]) and a high mPI (2.5 [1.4\u20134.3]) were independent risk factors. Moreover, low PlGF at 26\u201331\u00a0WG (3.3 [1.5\u20137.0]) was also an independent risk factor after adjusting for the effect of mPI. Concerning the occurrence of an SGA infant, a high mPI (2.8 [1.6\u20135.2]) and high sEng at 26\u201331\u00a0WG (2.3 [1.2\u20134.5]) were independent risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Low levels of PlGF at 19\u201325 and 26\u201331\u00a0WG were independent risk factors for a small placenta at \u226535\u00a0WG; and a high sEng at 26\u201331\u00a0WG was an independent risk factor for an SGA infant at \u226535\u00a0WG.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13360","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T10:32:52Z","timestamp":1497436372000},"page":"1285-1292","source":"Crossref","is-referenced-by-count":5,"title":["Independent risk factors for a small placenta and a small\u2010for\u2010gestational\u2010age infant at 35\u201341\u00a0weeks of gestation: An association with circulating angiogenesis\u2010related factor levels at 19\u201331\u00a0weeks of 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