{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T17:06:49Z","timestamp":1776445609641,"version":"3.51.2"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to evaluate the combined value of placental alpha microglobulin\u20101 (PAMG\u20101) and cervical length (CL) via transvaginal ultrasound for assessing risk of imminent spontaneous preterm delivery in patients presenting with threatened preterm labor (PTL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical exam, PAMG\u20101 test, cardiotocography, and CL measurement via transvaginal ultrasound were performed on all patients meeting inclusion criteria. Ninety\u2010nine patients at 22<jats:sup>+0<\/jats:sup>\u201336<jats:sup>+6<\/jats:sup> gestational weeks with the symptoms of PTL were included. The interval between sample collection and delivery was measured for each method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Performance metrics were calculated for PAMG\u20101 test, CL\u00a0&lt;\u00a025\u00a0mm, and contractions\u00a0\u2265\u00a08\/h. The sensitivity, specificity, positive predictive value, and negative predictive value for the PAMG\u20101 test were 100%, 95%, 75%, 100% and 100%, 98%, 88%, 100% for 7 and 14\u00a0days, respectively; the respective values for CL\u00a0&lt;\u00a025\u00a0mm were 83%, 59%, 22%, 96% and 79%, 59%, 24%, 94% for 7 and 14\u00a0days; and those for contractions\u00a0\u2265\u00a08\/h were 42%, 38%, 8%, 83% and 43%, 38%, 10%, 80% for 7 and 14\u00a0days. Specificity for the PAMG\u20101 test was statistically significant (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) in pairwise comparisons for all other methods. Patients were divided into four groups for analysis of PAMG\u20101 test performance as follows: CL\u00a0&lt;\u00a015\u00a0mm (100%, 100%, 100%, 100% and 100%, 100%, 100%, 100% for 7 and 14\u00a0days, respectively); CL\u00a0&lt;\u00a025\u00a0mm (100%, 94%, 83%, 100% and 100%, 97%, 92%, 100% for 7 and 14\u00a0days, respectively); CL of 15\u201330\u00a0mm (100%, 95%, 64%, 100% and 100%, 97%, 82%, 100% for 7 and 14\u00a0days, respectively); and CL\u00a0\u2265\u00a030\u00a0mm (100%, 100%, 100%, 100% and 100%, 100%, 100%, 100% for 7 and 14\u00a0days, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of the PAMG\u20101 test in patients with a CL of 15\u201330\u00a0mm is highly predictive of imminent spontaneous preterm delivery in women presenting with threatened PTL and could save hospital resources.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13366","type":"journal-article","created":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T10:32:56Z","timestamp":1497436376000},"page":"1263-1269","source":"Crossref","is-referenced-by-count":17,"title":["Combined value of placental alpha microglobulin\u20101 detection and cervical length via transvaginal ultrasound in the diagnosis of preterm labor in symptomatic patients"],"prefix":"10.1111","volume":"43","author":[{"given":"Vyacheslav","family":"Bolotskikh","sequence":"first","affiliation":[{"name":"North\u2010Western Branch, Russian Academy of Medical Sciences D.O. Ott Research Institute of Obstetrics and Gynecology  Saint Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera","family":"Borisova","sequence":"additional","affiliation":[{"name":"North\u2010Western Branch, Russian Academy of Medical Sciences D.O. Ott Research Institute of Obstetrics and Gynecology  Saint Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198501103120204"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181b47217"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000229"},{"key":"e_1_2_6_6_1","unstructured":"DuleyL.Tocolysis for women in preterm labour.Royal College of Obstetricians and Gynaecologists: Green\u2010top Guideline No. 1b.2011."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb02930.x"},{"key":"e_1_2_6_8_1","unstructured":"RobertsD.Antenatal corticosteroids to reduce neonatal morbidity and mortality.Royal College of Obstetricians and Gynaecologists: Green\u2010top Guideline No. 7.2010."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7457"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2014-0300"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-994079"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.10.890"},{"key":"e_1_2_6_13_1","first-page":"1","article-title":"Evaluation of a novel placental alpha microglobulin\u20101 (PAMG\u20101) test to predict spontaneous preterm delivery","volume":"13","author":"Nikolova T","year":"2013","journal-title":"J Perinat Med"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050902801694"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14742"},{"key":"e_1_2_6_16_1","first-page":"402","article-title":"Prediction and early detection of preterm labor","volume":"101","author":"Iams J","year":"2003","journal-title":"Am College Obstet Gynaecol"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.553694"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31818b1ff6"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.03.010"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13366","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.13366","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13366","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:28:32Z","timestamp":1693200512000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,14]]},"references-count":18,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/jog.13366"],"URL":"https:\/\/doi.org\/10.1111\/jog.13366","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,14]]}}}