{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T23:11:14Z","timestamp":1779145874827,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T00:00:00Z","timestamp":1496016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There have been few reports on the effects of everolimus on the fetus, but none of six infants with documented everolimus exposure <jats:italic>in utero<\/jats:italic> had congenital malformations. A 32\u2010year\u2010old nulliparous woman on everolimus (5.0\u00a0mg\/day) for renal angiomyolipoma (AML) due to tuberous sclerosis complex (TSC) was found to be pregnant at gestational week (GW) 7\u20135\/7, at which time everolimus was withheld. To control AML in this patient, transarterial embolization was performed in the right and left kidneys at GW 21 and 24, respectively, and everolimus was reinitiated at GW 25. The patient gave birth at GW 37 to a normally formed infant weighing 3057\u00a0g, but who had cardiac tumors thought to be rhabdomyomas due to inherited TSC. Thus, although data are still limited, everolimus may be promising with respect to teratogenicity. Everolimus concentration in the maternal and umbilical cord blood at birth was 1.1\u00a0ng\/mL and 1.0\u00a0ng\/mL, respectively.<\/jats:p>","DOI":"10.1111\/jog.13369","type":"journal-article","created":{"date-parts":[[2017,5,29]],"date-time":"2017-05-29T13:12:43Z","timestamp":1496063563000},"page":"1350-1352","source":"Crossref","is-referenced-by-count":25,"title":["Everolimus in pregnancy: Case report and literature review"],"prefix":"10.1111","volume":"43","author":[{"given":"Mie","family":"Yamamura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Obihiro Kosei Hospital  Obihiro Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hokkaido University Graduate School of Medicine  Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Koyama","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Obihiro Kosei Hospital  Obihiro Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ataru","family":"Sazawa","sequence":"additional","affiliation":[{"name":"Department of Urology Obihiro Kosei Hospital  Obihiro Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hokkaido University Graduate School of Medicine  Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisanori","family":"Minakami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hokkaido University Graduate School of Medicine  Sapporo Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,5,29]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra055323"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1086\/316951"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)63072-6"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329328"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2013.03.002"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61767-X"},{"key":"e_1_2_5_8_1","first-page":"43","article-title":"Birth defects in juvenile Wistar rats after exposure to immunosuppressive drugs during pregnancy","volume":"32","author":"Kabat\u2010Koperska J","year":"2017","journal-title":"Histol Histopathol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-2277.2011.01356.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2012.05.012"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2013.09.029"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tri.12479"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13514"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu526"},{"key":"e_1_2_5_15_1","first-page":"521","article-title":"Prenatal diagnosis of cardiac rhabdomyoma associated with tuberous sclerosis: Report of 3 cases","volume":"36","author":"Jurko T","year":"2015","journal-title":"Neuro Endocrinol Lett"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13369","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.13369","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T05:28:53Z","timestamp":1693200533000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,29]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/jog.13369"],"URL":"https:\/\/doi.org\/10.1111\/jog.13369","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,29]]}}}