{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T22:36:33Z","timestamp":1788561393404,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T00:00:00Z","timestamp":1499644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Turin, Italy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Abnormal placentation is a common pathogenic mechanism of many placenta\u2010mediated complications of late pregnancy, including pre\u2010eclampsia, fetal growth restriction, stillbirth, and placental abruption. During successful placentation, the trophoblast (which is a semi\u2010allograft) is not rejected by decidual immune cells because of maternal immune tolerance, mainly induced by human leukocyte antigen G (HLA\u2010G). Deficient HLA\u2010G expression seems to be associated with the development of complications of pregnancy. The aim of this study was to determine whether low soluble HLA\u2010G (sHLA\u2010G) levels in maternal blood at the beginning of pregnancy may be associated with subsequent placenta\u2010mediated complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>For this retrospective case\u2013control study, 117 cases of placenta\u2010mediated complications of pregnancy and 234 controls with uneventful pregnancy were selected. Plasma sHLA\u2010G levels were measured at 11\u201313\u00a0weeks' gestation by the enzyme\u2010linked immunosorbent assay method in blood samples previously obtained at first\u2010trimester prenatal screening for chromosomal fetal abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women who subsequently developed placenta\u2010mediated complications had significantly lower sHLA\u2010G levels at the beginning of pregnancy (median, 43.08\u00a0IU\/mL) than controls (median, 49.10\u00a0IU\/mL; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.008). An sHLA\u2010G level lower than 43.50\u00a0IU\/mL at the end of the first trimester was associated with a twofold increased risk of developing a pregnancy complication (odds ratio, 1.82; 95% confidence interval, 1.22\u20132.73). The strongest association, although only moderately strong, was observed with severe pre\u2010eclampsia (odds ratio, 2.66; 95% confidence interval, 1.08\u20136.56).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Placenta\u2010mediated complications of pregnancy may be associated with low sHLA\u2010G levels in the first trimester, suggesting a potential role of sHLA\u2010G in the early stages of placentation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13377","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T06:53:00Z","timestamp":1499669580000},"page":"1391-1396","source":"Crossref","is-referenced-by-count":20,"title":["Low expression of soluble human leukocyte antigen G in early gestation and subsequent placenta\u2010mediated complications of pregnancy"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9617-5301","authenticated-orcid":false,"given":"Luca","family":"Marozio","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Obstetrics and Gynecology University of Turin, Sant'Anna University Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Garofalo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Obstetrics and Gynecology University of Turin, Sant'Anna University Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Berchialla","sequence":"additional","affiliation":[{"name":"Department of Clinical and Biological Sciences University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Tavella","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Obstetrics and Gynecology University of Turin, Sant'Anna University Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Salton","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Obstetrics and Gynecology University of Turin, Sant'Anna University Hospital  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Cavallo","sequence":"additional","affiliation":[{"name":"Department of Public Health and Paediatrics University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Benedetto","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, Obstetrics and Gynecology University of Turin, Sant'Anna University Hospital  Turin 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