{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:24:56Z","timestamp":1791332696661,"version":"4.3.1"},"reference-count":23,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our aim was to investigate the effect of the prophylactic use of vaginal progesterone on the latency period from the initiation of tocolytic therapy to delivery in twin pregnancies with preterm labor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a secondary analysis of a randomized, double\u2010blind, placebo\u2010controlled trial of twin pregnancies in mothers who were exposed to a 200\u00a0mg vaginal progesterone ovule or a placebo ovule daily from 18 to 34\u00a0weeks gestation. Patients who were administered tocolysis with Atosiban because of preterm labor were included. The latency from tocolysis to delivery, mean gestational age at delivery and the rates of delivery within 48\u00a0h and within seven days were compared between progesterone and placebo groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The analysis included 27 women in the progesterone group and 30 in the placebo group. The baseline characteristics were similar between the groups. Overall, there were no differences in the latency period to delivery (17.54\u00a0\u00b1\u00a013.54\u00a0days and 21.58\u00a0\u00b1\u00a013.52\u00a0days; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.289), rates of delivery within 48\u00a0h (14.8% and 6.7%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.40) or within seven days (29.64% and 23.3%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.76) or mean gestational age at delivery (32.53\u00a0\u00b1\u00a03.33 and 34.13\u00a0\u00b1\u00a02.87; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.08) between the progesterone and placebo groups, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prophylactic use of 200\u00a0mg of vaginal progesterone does not influence the latency to delivery in women with twin pregnancies treated with tocolysis because of preterm labor.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13421","type":"journal-article","created":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T11:47:01Z","timestamp":1500032821000},"page":"1536-1542","source":"Crossref","is-referenced-by-count":5,"title":["Effect of vaginal progesterone in tocolytic therapy during preterm labor in twin pregnancies: Secondary analysis of a placebo\u2010controlled randomized trial"],"prefix":"10.1111","volume":"43","author":[{"given":"Wagner R.","family":"Hernandez","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology S\u00e3o Paulo University Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossana P.V.","family":"Francisco","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology S\u00e3o Paulo University Medical School  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto 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