{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T22:48:21Z","timestamp":1783118901674,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The objective of this study was to determine how many pregnant Japanese women with diabetes mellitus (DM)\/gestational diabetes mellitus (GDM) experience perinatal mortality in the presence of fetal anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our investigation included data from 205 secondary\/tertiary obstetric facilities located widely in Japan. The Japan Ministry of Health, Labour and Welfare Vital Statistics of Japan was used for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 237 941 women giving birth at 205 hospitals, 1796 (0.8%) and 13 037 (5.5%) had DM and GDM, respectively. The perinatal mortality rates (per 1000 births) were 10.6 (19\/1796) for women with DM, 5.2 (68\/13037) for women with GDM, and 3.7 (7612\/2039504) for the general Japanese population. Detailed information was available for 63 (72%) of the 87 perinatal deaths occurring in women with diabetes including DM and GDM; fetal anomalies were associated with 40% (25\/63) of perinatal deaths, exceeding 16% (1211\/7612) in the general Japanese population (<jats:italic>P<\/jats:italic> &lt; 0.0001). The leading four fetal anomalies associated with perinatal mortality in women with diabetes were fetal trisomy (6 cases: 1 of trisomy\u201013 and 5 of trisomy\u201018), non\u2010immune hydrops fetalis (5 cases), cardiac deformities (3 cases) and holoprosencephaly (2 cases).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Perinatal mortality was more likely to occur in women with glucose intolerance. In the Japanese infants that succumbed to perinatal mortality, fetal anomaly was more prevalent in those born to women with a glucose intolerance than in those born to the general population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13431","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T15:42:36Z","timestamp":1502984556000},"page":"1700-1707","source":"Crossref","is-referenced-by-count":16,"title":["Perinatal mortality in Japanese women diagnosed with gestational diabetes mellitus and diabetes mellitus"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-5422","authenticated-orcid":false,"given":"Mamoru","family":"Morikawa","sequence":"first","affiliation":[{"name":"Department of Obstetrics Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ehime University Graduate School of Medicine  Matsuyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimasa","family":"Sagawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kyoto Rakuwa\u2010kai Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Hiramatsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Okayama University Graduate School of Medicine, Dentistry Pharmaceutical Science  Okayama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanagawa Children's Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Tsukuba Hospital  Tukuba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kameda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Gunma University Hospital  Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiko","family":"Hara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kyushu University Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Toda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Anjo Kosei Hospital  Anjo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5533-1339","authenticated-orcid":false,"given":"Hisanori","family":"Minakami","sequence":"additional","affiliation":[{"name":"Department of Obstetrics Hokkaido University Graduate School of Medicine  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.6.3.219"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.19.5.514"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.2831"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.127458"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2007.00484.x"},{"key":"e_1_2_7_7_1","first-page":"229","article-title":"Sudden fetal death in women with well\u2010controlled, intensively monitored gestational diabetes","volume":"12","author":"Girz BA","year":"1992","journal-title":"J Perinatol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707943"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000010131"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1848"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2011.01653.x"},{"key":"e_1_2_7_12_1","volume-title":"Vital Statistics of Japan 2013","author":"Health, Labour and Welfare Statistics Association","year":"2015"},{"key":"e_1_2_7_13_1","volume-title":"Vital Statistics of Japan 2014","author":"Health, Labour and Welfare Statistics Association","year":"2016"},{"key":"e_1_2_7_14_1","first-page":"1432","article-title":"Reestimating date of delivery in multifetal pregnancies. 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