{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T07:45:59Z","timestamp":1778744759259,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T00:00:00Z","timestamp":1502928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004935","name":"S\u00fcleyman Demirel \u00dcniversitesi","doi-asserted-by":"publisher","award":["4545\u2010TU2\u201016"],"award-info":[{"award-number":["4545\u2010TU2\u201016"]}],"id":[{"id":"10.13039\/501100004935","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Fingolimod is a sphingosine\u20101\u2010phosphate receptor modulator used for multiple sclerosis treatment and acts on cellular processes such as apoptosis, endothelial permeability, and inflammation. We hypothesized that fingolimod has a positive effect on alleviating preterm fetal brain injury.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen pregnant rats were divided into four groups of four rats each. On gestational day 17, i.p. endotoxin was injected to induce fetal brain injury, followed by i.p. fingolimod (4 mg\/kg maternal weight). Hysterotomy for preterm delivery was performed 6 h after fingolimod. The study groups included (i) vehicle controls (i.p. normal saline only); (ii) positive controls (endotoxin plus saline); (iii) saline plus fingolimod; and (iv) endotoxin plus fingolimod treatment. Brain tissues of the pups were dissected for evaluation of interleukin (IL)\u20106, caspase\u20103, and S100\u03b2 on immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal fingolimod treatment attenuated endotoxin\u2010related fetal brain injury and led to lower immunoreactions for IL\u20106, caspase\u20103, and S100\u03b2 compared with endotoxin controls (<jats:italic>P<\/jats:italic> &lt; 0.0001 for all comparisons).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Antenatal maternal fingolimod therapy had fetal neuroprotective effects by alleviating preterm birth\u2010related fetal brain injury with inhibitory effects on inflammation and apoptosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13444","type":"journal-article","created":{"date-parts":[[2017,8,17]],"date-time":"2017-08-17T13:52:41Z","timestamp":1502977961000},"page":"1708-1713","source":"Crossref","is-referenced-by-count":12,"title":["Fingolimod against endotoxin\u2010induced fetal brain injury in a rat model"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5969-4444","authenticated-orcid":false,"given":"And","family":"Yavuz","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology S\u00fcleyman Demirel University School of Medicine, SDU Campus  Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6989-081X","authenticated-orcid":false,"given":"Mekin","family":"Sezik","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology S\u00fcleyman Demirel University School of Medicine, SDU Campus  Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozlem","family":"Ozmen","sequence":"additional","affiliation":[{"name":"Department of Pathology Mehmet Akif Ersoy University Faculty of Veterinary Medicine  Burdur Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil","family":"Asci","sequence":"additional","affiliation":[{"name":"Department of Pharmacology S\u00fcleyman Demirel University School of Medicine, SDU Campus  Isparta Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60136-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-956773"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12882"},{"key":"e_1_2_7_5_1","first-page":"46211","article-title":"Neonatal outcomes following preterm birth classified according to placental features","volume":"9378","author":"Catov JM","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22049"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2014-0176"},{"key":"e_1_2_7_8_1","first-page":"1","article-title":"Neuroprotective effects of antenatal magnesium sulfate under inflammatory conditions in a Sprague\u2010Dawley pregnant rat model","volume":"31","author":"Binette A","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0b013e3181cbf825"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-011-0216-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.03.014"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.05.031"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2015.10.004"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000137"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285616631897"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2011.01010.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.09.004"},{"key":"e_1_2_7_18_1","first-page":"CD010527","article-title":"Melatonin for women in pregnancy for neuroprotection of the fetus","volume":"3","author":"Wilkinson D","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.05.012"},{"key":"e_1_2_7_20_1","first-page":"CD010846","article-title":"Creatine for women in pregnancy for neuroprotection of the fetus","volume":"12","author":"Dickinson H","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20261"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20421"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-015-1526-y"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000105493"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.06.027"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.12703\/P6-6"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13444","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13444","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:39:53Z","timestamp":1695976793000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,17]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/jog.13444"],"URL":"https:\/\/doi.org\/10.1111\/jog.13444","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,17]]}}}