{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:28:04Z","timestamp":1740126484904,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T00:00:00Z","timestamp":1505088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to evaluate the clinical usefulness of serum squamous cell carcinoma (SCC) antigen for the diagnosis of amniotic fluid embolism (AFE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sera and information of 20 patients with AFE (autopsy\u2010proven AFE, four cases; clinical AFE, 16 cases) were obtained from the Japan Amniotic Fluid Embolism Registration Center at Hamamatsu University School of Medicine. As controls, we included 74 gestational\u2010age\u2010matched healthy women who gave birth to healthy newborns during the period from December 2012 to January 2014. Receiver\u2013operator curves (ROC) were used to evaluate the diagnostic performance of SCC levels for prediction of AFE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum SCC antigen levels in women with autopsy\u2010proven AFE (112.0 \u00b1 169.4 ng\/mL, <jats:italic>P<\/jats:italic> = 0.001) and clinical AFE (9.5 \u00b1 10.3 ng\/mL, <jats:italic>P<\/jats:italic> = 0.004) were significantly higher than those in healthy controls with normal delivery (4.4 \u00b1 2.2 ng\/mL). On ROC analysis, the optimal cut\u2010off value for SCC antigen levels was 7.15 ng\/mL, for which the sensitivity and specificity for AFE prediction was 60.0% and 89.2%, respectively (area under the ROC, 0.785; 95% confidence interval, 0.663\u20130.908; <jats:italic>P<\/jats:italic> &lt; 0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum SCC antigen may be a promising predictor of the entry of amniotic fluid into the maternal circulation, potentially serving as a candidate marker for noninvasive diagnosis of AFE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13453","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T15:36:28Z","timestamp":1505144188000},"page":"1815-1820","source":"Crossref","is-referenced-by-count":1,"title":["Squamous cell carcinoma antigen as a novel candidate marker for amniotic fluid embolism"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5156-7061","authenticated-orcid":false,"given":"Natsuki","family":"Koike","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Oi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kindai University Nara Hospital  Ikoma Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"Naruse","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiro","family":"Kanayama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hamamatsu University School of Medicine  Hamamatsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nara Medical University  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1080\/00016340902971474"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.2174\/1874291201206010024"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1093\/clinchem\/38.4.526","article-title":"Determining zinc coproporphyrin in maternal plasma: A new method for diagnosing amniotic fluid embolism","volume":"38","author":"Kanayama N","year":"1992","journal-title":"Clin 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