{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:27Z","timestamp":1787015547173,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T00:00:00Z","timestamp":1507248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Risk factors for cisplatin\u2010induced nephrotoxicity (CIN) vary by population. This study aimed to assess risk factors for CIN in patients with gynecological cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who underwent cisplatin\u2010based chemotherapy for gynecological cancer between January 2009 and December 2015 at Aichi Medical University School of Medicine were included in this study. CIN was defined according to the \u2018risk, injury, failure, loss, and end\u2010stage kidney disease\u2019 (RIFLE) criteria and classified as either risk (Class R) or injury (Class I). Analyses were performed using univariate and multivariate logistic regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 112 patients enrolled, 30 had CIN. Multivariate analysis revealed that hydration with magnesium (odds ratio [OR], 0.223), history of cisplatin use (OR, 4.420), and hypoalbuminemia (OR, 4.170) were risk factors for Class R, and that frequency of cisplatin administration (OR, 5.620) and hydration with magnesium (OR, 0.216) were risk factors for Class I.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study confirmed that hydration without magnesium, history of cisplatin use, frequency of cisplatin administration, and hypoalbuminemia are significant risk factors for CIN.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.13457","type":"journal-article","created":{"date-parts":[[2017,10,6]],"date-time":"2017-10-06T04:26:38Z","timestamp":1507263998000},"page":"1880-1886","source":"Crossref","is-referenced-by-count":15,"title":["Multivariate analysis of risk factors for cisplatin\u2010induced nephrotoxicity in gynecological cancer"],"prefix":"10.1111","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1143-5830","authenticated-orcid":false,"given":"Yoshihiro","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Pharmacy Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazushi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8219-9011","authenticated-orcid":false,"given":"Hiroshi","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuto","family":"Tsukiyama","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Aichi Medical University School of Medicine  Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Wakatsuki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Aichi Medical University School of Medicine  Aichi 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effects of hydration with magnesium in patients with cervical cancer receiving cisplatin","volume":"35","author":"Yamamoto Y","year":"2015","journal-title":"Anticancer Res"},{"key":"e_1_2_7_12_1","first-page":"1873","article-title":"Hydration with 15 mEq magnesium is effective at reducing the risk for cisplatin\u2010induced nephrotoxicity in patients receiving cisplatin (\u226550 mg\/m2) combination chemotherapy","volume":"36","author":"Yamamoto Y","year":"2016","journal-title":"Anticancer Res"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.2.304"}],"container-title":["Journal of Obstetrics and Gynaecology 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