{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:53:43Z","timestamp":1790898823404,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T00:00:00Z","timestamp":1505865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Increasing evidence has suggested that chromium supplementation may improve the clinical symptoms of polycystic ovary syndrome (PCOS), yet the results have been inconsistent. To derive a more precise estimation of the efficacy of chromium, a meta\u2010analysis was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Studies published in PubMed, EMBASE and the Cochrane Library up to April 2017 were retrieved. Standardized mean differences (SMD) with 95%CI were calculated for net changes using random\u2010effects or fixed\u2010effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of six randomized clinical trials (RCT) with 351 PCOS women were ultimately collected in this meta\u2010analysis. All included RCT were of moderate\u2013high quality. On pooled analysis, insulin resistance was significantly decreased (SMD, \u22120.84; 95%CI: \u22121.30 to \u22120.38; <jats:italic>P<\/jats:italic> = 0.0004), while the total testosterone (SMD, 0.36; 95%CI: 0.07\u20130.65; <jats:italic>P<\/jats:italic> = 0.02) and free testosterone (SMD, 0.80; 95%CI: 0.48\u20131.12; <jats:italic>P<\/jats:italic> &lt; 0.00001) were markedly increased in chromium\u2010treated PCOS patients compared with control groups. No significant difference was found in other indexes of insulin metabolism (body mass index, fasting insulin, fasting blood sugar and quantitative insulin sensitivity check index), hormone status (luteinizing hormone, follicle\u2010stimulating hormone and prolactin) and lipid profiles (cholesterol and triglycerides) between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Supplementation with chromium may not have significant benefits for women with PCOS. More RCT with low heterogeneity, however, are required to corroborate the present findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13462","type":"journal-article","created":{"date-parts":[[2017,9,20]],"date-time":"2017-09-20T05:06:45Z","timestamp":1505884005000},"page":"134-143","source":"Crossref","is-referenced-by-count":22,"title":["Chromium supplementation in women with polycystic ovary syndrome: Systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"44","author":[{"given":"Xiao\u2010Lei","family":"Tang","sequence":"first","affiliation":[{"name":"Taishan Medical College  Taian Shandong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Sun","sequence":"additional","affiliation":[{"name":"Taishan Medical College  Taian Shandong Province 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