{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:52:43Z","timestamp":1772574763977,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T00:00:00Z","timestamp":1509580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Abstract<\/jats:title>A 63\u2010year\u2010old woman presented with abnormal vaginal bleeding. Her disease history was significant, and included advanced lung adenocarcinoma with a deletion mutation in exon 19 of the epidermal growth factor receptor (EGFR<\/jats:italic><\/jats:styled-content>) gene, which was managed by concurrent chemoradiotherapy, followed by molecular targeted therapy with tyrosine kinase inhibitors (TKI<\/jats:styled-content>s) for a two\u2010year period. Contrast\u2010enhanced computed tomography showed the enlargement of a previously suspicious myoma node, with peripheral enhancement. Hemorrhagic necrosis was also observed on magnetic resonance imaging. Transabdominal hysterectomy and bilateral salpingo\u2010oophorectomy showed solitary intramyometrial metastatic lung adenocarcinoma with a second\u2010site T<\/jats:styled-content>790M<\/jats:styled-content> gatekeeper mutation in exon 20 of the EGFR<\/jats:italic><\/jats:styled-content> gene. In conclusion, uterine metastasis from lung adenocarcinoma can present a diagnostic challenge. The possibility of lung cancer metastasis should be considered when a uterine mass increases in size during treatment. Molecular analysis of the EGFR<\/jats:italic><\/jats:styled-content> gene to detect mutations could provide useful information for planning the treatment strategy.<\/jats:p>","DOI":"10.1111\/jog.13493","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T07:59:44Z","timestamp":1509609584000},"page":"352-358","source":"Crossref","is-referenced-by-count":5,"title":["Uterine metastasis of lung adenocarcinoma under molecular target therapy with epidermal growth factor receptor tyrosine kinase inhibitors: A<\/scp> case report and review of the literature"],"prefix":"10.1111","volume":"44","author":[{"given":"Mayu","family":"Shibata","sequence":"first","affiliation":[{"name":"Departments of Obstetrics and Gynecology Gifu Prefectural Tajimi Hospital Tajimi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Shizu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Gifu Prefectural Tajimi Hospital Tajimi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Gifu Prefectural Tajimi Hospital Tajimi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Takeda","sequence":"additional","affiliation":[{"name":"Departments of Obstetrics and Gynecology Gifu Prefectural Tajimi Hospital Tajimi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.03.007"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821115)50:10<2163::AID-CNCR2820501032>3.0.CO;2-F"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089161109700326"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.892495"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrc.2015.08.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2017.02.001"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405220101"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.06.009"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.12211"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000439"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-10-2571"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1097\/JTO.0b013e31827e1f83","article-title":"Local therapy with continued EGFR tyrosine kinase inhibitor therapy as a treatment strategy in EGFR\u2010mutant advanced lung cancers that have developed acquired resistance to EGFR tyrosine kinase inhibitors","volume":"8","author":"HA Y","year":"2013","journal-title":"J Thorac Oncol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1468"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T01:23:58Z","timestamp":1695777838000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,2]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/jog.13493"],"URL":"https:\/\/doi.org\/10.1111\/jog.13493","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,2]]}}}