{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T21:53:52Z","timestamp":1769723632281,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T00:00:00Z","timestamp":1516233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to determine the relationship between serum amyloid <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">SAA)<\/jats:styled-content>, procalcitonin <jats:styled-content style=\"fixed-case\">(P<\/jats:styled-content>ro<jats:styled-content style=\"fixed-case\">C)<\/jats:styled-content>, highly sensitive <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> reactive protein (hs<jats:styled-content style=\"fixed-case\">CRP)<\/jats:styled-content> and tumor necrosis factor (<jats:styled-content style=\"fixed-case\">TNF)<\/jats:styled-content> alpha activity in patients with pre\u2010eclampsia, eclampsia and hemolysis, elevated liver enzymes, low platelet count (<jats:styled-content style=\"fixed-case\">HELLP)<\/jats:styled-content>, and the pathogenesis and severity of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Ninety patients at \u2265 32 gestational weeks, according to the last date of menstruation and ultra\u2010sonographic measurements, diagnosed with pre\u2010eclampsia (30 patients), eclampsia (30 patients) or <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> syndrome (30 patients) were included in the study. Thirty healthy pregnant women from the outpatient clinic during the same period were recruited as the control. The age, gravida, parity, gestational age, systolic and diastolic blood pressures, proteinuria, hemoglobin, thrombocyte count, liver function tests (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, <jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> alpha, <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ro<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> and hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> levels during pregnancy) were determined and recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant differences were detected between the four groups in terms of age, gravida, parity, gestational age and <jats:styled-content style=\"fixed-case\">hemoglobin<\/jats:styled-content> parameters (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). When compared to the control, systolic and diastolic blood pressures, spot and 24\u2009h urine protein levels, aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, <jats:styled-content style=\"fixed-case\">SAA<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>ro<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>, hs<jats:styled-content style=\"fixed-case\">CRP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> alpha levels were significantly high and thrombocyte levels were low in the pre\u2010eclamptic, eclamptic and <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The investigated parameters were useful to gain an understanding of the maternal inflammatory profile of pre\u2010eclampsia and might be beneficial as markers to predict complications such as <jats:styled-content style=\"fixed-case\">HELLP<\/jats:styled-content> and eclampsia and to provide the necessary preventive approach in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13532","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T09:15:35Z","timestamp":1516266935000},"page":"440-447","source":"Crossref","is-referenced-by-count":16,"title":["Serum amyloid A, procalcitonin, highly sensitive C reactive protein and tumor necrosis factor alpha levels and acute inflammatory response in patients with hemolysis, elevated liver enzymes, low platelet count (HELLP) and eclampsia"],"prefix":"10.1111","volume":"44","author":[{"given":"Kaz\u0131m","family":"Uckan","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Training and Research Hospital  Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han\u0131m Guler","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics School of Medicine, YuzuncuYil University  Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,18]]},"reference":[{"issue":"4","key":"e_1_2_7_2_1","first-page":"17","article-title":"Pregnancy\u2010related mortality surveillance: United States, 1987\u20131900","volume":"46","author":"Koonin LM","year":"1997","journal-title":"CDC MMWR Surveill Summ"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(01)01747-1"},{"key":"e_1_2_7_4_1","first-page":"357","article-title":"Risk factors for severe preeclampsia","volume":"83","author":"Stone JL","year":"1994","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_5_1","first-page":"1055","article-title":"Maternal mortality in the United States, 1979\u20131986","volume":"76","author":"Atrash HK","year":"1990","journal-title":"Obstet 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