{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T11:33:13Z","timestamp":1789903993261,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The effectiveness of vaginal progesterone for maintenance tocolysis after arrested preterm labor remains controversial. Myometrial contractility can be assessed objectively and non\u2010invasively after progesterone treatment by monitoring uterine electromyography (EMG). We examined the effects of vaginal progesterone on uterine EMG after successful acute tocolysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized, double\u2010blind, single\u2010center study performed between 2012 and 2015. Thirty women who experienced preterm labor between 24 0\/7 and 33 6\/7\u2009weeks were randomly allocated to groups administered either 400\u2009mg vaginal progesterone or a placebo 48\u2009h after acute tocolysis. EMG measurements were taken prior to and 1 h and 2\u2009h following treatment. Mann\u2013Whitney <jats:italic>U<\/jats:italic> tests were used to compare EMG power density spectrum peak frequency and peak amplitude, propagation velocity of EMG signals, and duration and number of EMG bursts in 30\u2009min recordings between the groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EMG propagation velocity was higher in patients receiving the placebo compared to those treated with progesterone at 1\u2009h (27.83\u2009\u00b1\u200910.66 vs 15.60\u2009\u00b1\u20092.94\u2009cm\/s) and 2\u2009h (26.97\u2009\u00b1\u200913.39 vs 15.12\u2009\u00b1\u20092.58\u2009cm\/s) following treatment (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). PDS peak frequencies were higher in the placebo compared to the progesterone group at 2\u2009h following treatment (0.54\u2009\u00b1\u20090.11 vs 0.44\u2009\u00b1\u20090.06\u2009Hz; <jats:italic>P<\/jats:italic> =\u20090.003).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Treatment of 400\u2009mg of vaginal micronized progesterone as maintenance tocolysis significantly reduces the propagation velocity of electrical signals within the myometrium and is associated with a shift toward lower uterine electrical signal frequencies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13545","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T11:53:18Z","timestamp":1514980398000},"page":"408-416","source":"Crossref","is-referenced-by-count":9,"title":["Effects of vaginal progesterone for maintenance tocolysis on uterine electrical activity"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-9175","authenticated-orcid":false,"given":"Miha","family":"Lucovnik","sequence":"first","affiliation":[{"name":"Department of Perinatology, Division of Obstetrics and Gynecology University Medical Center Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreja","family":"Trojner Bregar","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Division of Obstetrics and Gynecology University Medical Center Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Bombac","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Division of Obstetrics and Gynecology University Medical Center Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ksenija","family":"Gersak","sequence":"additional","affiliation":[{"name":"Department of Perinatology, Division of Obstetrics and Gynecology University Medical Center Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Garfield","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Guangzhou Women and Children's Medical Center  Guangzhou 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