{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:47:48Z","timestamp":1790711268462,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Obstetrics and Gynaecology, University of Ruhuna"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n This study was conducted to determine whether weekly antenatal oral iron and folate supplementation is an effective alternative to a daily regimen in non\u2010anemic pregnant women to prevent anemia and iron deficiency during the third trimester.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n From December 2014 to April 2015, non\u2010anemic pregnant women (\n n<\/jats:italic>\n \u2009=\u2009292) who presented to the Academic Obstetric Unit, Teaching Hospital Mahamodera Galle, Sri Lanka, at 14\u201322\u2009weeks gestation and who had been treated with mebendazole 100\u2009mg twice daily for three\u2009days were randomly allocated to receive 120\u2009mg elemental iron, 3\u2009mg folic acid and 100\u2009mg vitamin C weekly (\n n<\/jats:italic>\n \u2009=\u2009149) or 60\u2009mg elemental iron, 1\u2009mg folic acid and 100\u2009mg vitamin C daily (\n n<\/jats:italic>\n \u2009=\u2009143). Side effects were assessed at four weekly intervals and hemoglobin concentration (Hb), hematocrit and serum ferritin (SF) were measured at 32\u201336\u2009weeks gestation.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Only 106 participants in each group completed the study. There were no significant differences between the groups in mean duration of supplementation; presupplementation and post\u2010supplementation mean Hb, hematocrit or SF levels; risk of developing anemia, ID or high Hb levels by an intension to treat analysis; and in those who completed the trial. Significantly greater side effects occurred in the daily compared to the weekly supplementation group.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n In non\u2010anemic pregnant women, a weekly regimen is an effective alternative to a daily regimen for antenatal oral iron and folate supplementation for preventing anemia and iron deficiency during the third trimester.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jog.13546","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T10:46:50Z","timestamp":1514026010000},"page":"417-424","source":"Crossref","is-referenced-by-count":16,"title":["Randomized control trial comparing effectiveness of weekly versus daily antenatal oral iron supplementation in preventing anemia during pregnancy"],"prefix":"10.1111","volume":"44","author":[{"given":"Indra Malik R.","family":"Goonewardene","sequence":"first","affiliation":[{"name":"Academic Obstetrics and Gynaecology Unit Teaching Hospital Galle Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diluk I.","family":"Senadheera","sequence":"additional","affiliation":[{"name":"Academic Obstetrics and Gynaecology Unit Teaching Hospital Galle Sri Lanka"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Guideline: Daily Iron and Folic Acid Supplementation in Non\u2010anaemic Pregnant Women","author":"World Health Organization","year":"2012"},{"key":"e_1_2_7_3_1","volume-title":"Guideline: Intermittent Iron and Folic Acid Supplementation in Non\u2010anaemic Pregnant Women","author":"World Health Organization","year":"2012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-005-3708-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-9796(03)00039-1"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.3.340"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.11.011"},{"key":"e_1_2_7_8_1","first-page":"CD009997","article-title":"Intermittent oral iron supplementation during pregnancy","author":"Pe\u00f1a\u2010Rosas JP","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/133.5.1700S"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3181\/0708-RM-233"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2012.03.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4038\/cmj.v46i4.6440","article-title":"Intermittent oral iron supplementation during pregnancy","volume":"46","author":"Goonewardene M","year":"2001","journal-title":"Ceylon Med J"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.11.2697"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/004947550003000210"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2011.10.010"},{"key":"e_1_2_7_16_1","first-page":"175","article-title":"Do side\u2010effects reduce compliance to iron supplementation? 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Kurunegala District","author":"Jayatissa R","year":"2010"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.4038\/cmj.v57i3.4148"},{"key":"e_1_2_7_22_1","volume-title":"Demographic and Health Survey 2006\/7: Prevalence of Anaemia among Children and Women","author":"Department of Census and Statistics","year":"2009"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1783"},{"key":"e_1_2_7_24_1","unstructured":"SenadheeraD GoonewardeneM. Randomised control trial comparing effectiveness of weekly versus daily antenatal oral iron supplementation in preventing anemia during pregnancy. Sri Lanka Clinical Trials Registry No. SLCTR\/2014\/032. [Cited 23 Aug 2016]. 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