{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:14:06Z","timestamp":1792512846076,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T00:00:00Z","timestamp":1514937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Thyroid dysfunction and autoimmunity are associated with an adverse effect on fertility. An aberrant high thyroid stimulating hormone level is associated with diminished ovarian reserve in women of reproductive age; however, the utility of levothyroxine (LT4) replacement for infertile patients with subclinical hypothyroidism is still under discussion. The aim of this study was to investigate whether LT4 supplementation for infertile patients with subclinical hypothyroidism improves impaired ovarian function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We measured levels of serum thyroid\u2010related hormones and a biomarker of ovarian function, anti\u2010M\u00fcllerian hormone (AMH) in infertile women from 2014 to 2015. Out of a consecutive 1431 infertile patients, 311 patients with an elevated thyroid stimulating hormone level (\u2265 2.5\u2009\u03bcIU\/mL) underwent detailed thyroid examinations, including blood tests of thyroid antibodies. We recruited 174 infertile patients, excluding patients with factors impacting ovarian and thyroid function. We evaluated alterations in AMH and thyroid related hormone levels during LT4 supplementation and infertility treatment with assisted reproductive technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After LT4 supplementation, no significant change in the average AMH level was detected overall. However, the AMH level in 35 patients with Hashimoto\u2019s disease increased significantly after treatment (1\u2009month 1.3\u2009\u00b1\u20090.5 fold, <jats:italic>P<\/jats:italic>\u2009=\u20090.007; 3\u2009months 1.3\u2009\u00b1\u20090.4 fold, <jats:italic>P<\/jats:italic>\u2009=\u20090.040). The AMH level in patients with thyroglobulin antibody\u2010positive and thyroid peroxidase antibody\u2010negative also significantly increased after LT4 treatment (1 and 3\u2009months 1.5 fold; <jats:italic>P<\/jats:italic>\u2009=\u20090.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the patients with Hashimoto\u2019s disease, preconception LT4 treatment may relieve adverse effects, including autoimmune antibodies, and support follicular development.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13554","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T11:48:52Z","timestamp":1514980132000},"page":"739-746","source":"Crossref","is-referenced-by-count":27,"title":["Levothyroxine supplementation improves serum anti\u2010M\u00fcllerian hormone levels in infertile patients with Hashimoto\u2019s thyroiditis"],"prefix":"10.1111","volume":"44","author":[{"given":"Masako","family":"Kuroda","sequence":"first","affiliation":[{"name":"Shinbashi Yume Clinic  Tokyo Japan"},{"name":"Natural ART Clinic Nihonbashi  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University, Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Segawa","sequence":"additional","affiliation":[{"name":"Shinbashi Yume Clinic  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeduk Y.","family":"Noh","sequence":"additional","affiliation":[{"name":"Ito Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Ito Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Ito Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Osada","sequence":"additional","affiliation":[{"name":"Natural ART Clinic Nihonbashi  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University, Faculty of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shokichi","family":"Teramoto","sequence":"additional","affiliation":[{"name":"Shinbashi Yume Clinic  Tokyo Japan"},{"name":"Natural ART Clinic Nihonbashi  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908193410801"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03743.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0141"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2009-0041"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr024"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.02.056"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0397-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1340649"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP09365.OR"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms052"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-2803"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60701-8"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.06.007"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.18.1.107"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00077-X"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dev089"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra021194"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.2.8182"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.1160019"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/reprod\/119.2.193"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061947"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)55974-3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0897.2010.00961.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02994446"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1869"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2669"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1306189110"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206600109"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2015.1116510"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1977.tb01340.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.1995.tb01894.x"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-017-0257-2"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.05.063"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3109\/09513590.2014.926324"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13554","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T21:50:12Z","timestamp":1694382612000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,3]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1111\/jog.13554"],"URL":"https:\/\/doi.org\/10.1111\/jog.13554","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,3]]}}}