{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T22:37:14Z","timestamp":1758926234001,"version":"3.37.3"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National High-tech R&D Program of China","award":["2014AA022304"],"award-info":[{"award-number":["2014AA022304"]}]},{"name":"Ministry of Science and Technology of China"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We aimed to explore the relation between the level of adipocyte fatty\u2010acid binding protein (A\u2010FABP) in the gestational period and related indices of glucolipid metabolism, and the possible mechanisms of occurrence and development of pre\u2010eclampsia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seventy\u2010six pre\u2010eclampsia patients were enrolled and divided into the mild pre\u2010eclampsia (<jats:italic>n<\/jats:italic>\u2009=\u200942) and severe pre\u2010eclampsia (<jats:italic>n<\/jats:italic>\u2009=\u200934) groups. Forty\u2010eight healthy pregnant women were selected as a control group. The indices of all participants were examined, including serum A\u2010FABP, fasting insulin (FINS), fasting blood glucose, total cholesterol (TC), triglycerides (TG), low\u2010density lipoprotein (LDL), and high\u2010density lipoprotein (HDL), and homeostatic model assessment insulin resistance (HOMA\u2010IR) index was calculated. After the delivery of the placenta, the level of A\u2010FABP in the placenta was detected by immunochemistry. Then, the correlation between serum A\u2010FABP and indices of glucolipid metabolism and placental A\u2010FABP were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum A\u2010FABP, FINS, TG, TC, HOMA\u2010IR, and placental A\u2010FABP were significantly higher in pre\u2010eclampsia patients and the level of HDL was obviously lower than in the control group. Serum A\u2010FABP was positively correlated with FINS, TG, TC, and HOMA\u2010IR, and placental A\u2010FABP was negatively correlated with HDL in pre\u2010eclampsia patients. In the control group, serum A\u2010FABP was positively correlated only with TG, and uncorrelated with the other indices (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The level of A\u2010FABP was correlated with insulin resistance and indices of glucolipid metabolism in pre\u2010eclampsia patients. High\u2010levels of A\u2010FABP might increase insulin resistance by causing glucose and lipid metabolism disorders and ultimately inducing the occurrence and development of pre\u2010eclampsia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13557","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T02:09:52Z","timestamp":1515550192000},"page":"655-662","source":"Crossref","is-referenced-by-count":10,"title":["Study on the correlation between adipocyte fatty\u2010acid binding protein, glucolipid metabolism, and pre\u2010eclampsia"],"prefix":"10.1111","volume":"44","author":[{"given":"Yan\u2010Ping","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory The Third Hospital of Xiamen  Xiamen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cai\u2010Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology and Obstetrics The Third Hospital of Xiamen  Xiamen 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