{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T14:41:30Z","timestamp":1769524890079,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,5]],"date-time":"2018-01-05T00:00:00Z","timestamp":1515110400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai","doi-asserted-by":"publisher","award":["17ZR141400"],"award-info":[{"award-number":["17ZR141400"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To date, reported associations between methylenetetrahydrofolate reductase (<jats:italic>MTHFR<\/jats:italic>) gene polymorphisms and preterm delivery are conflicting. The present meta\u2010analysis summarized the existing evidence and evaluated these associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eligible studies were retrieved from Medline (PubMed), EMBASE, the Chinese Biomedical Literature Database and the Cochrane Library. We calculated pooled odds ratios (ORs) and 95% confidence interval (CIs) within five genetic models using either random\u2010effects or fixed\u2010effects models dependent on study heterogeneity. Potential publication bias was assessed using a Begg\u2019s test. Sensitivity analysis was performed to evaluate the stability of the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirteen studies involving 4816 mothers who experienced preterm delivery and 34\u2009506 normal controls were finally included. Significant associations between <jats:italic>MTHFR<\/jats:italic> C677T polymorphism and the risk of preterm delivery were detected overall (OR<jats:sub>T\/C<\/jats:sub>\u2009=\u20091.34, 95% CI 1.12\u20131.61; OR<jats:sub>TT\/CC<\/jats:sub>\u2009=\u20091.60, 95% CI 1.21\u20132.11; OR<jats:sub>CT\/CC<\/jats:sub>\u2009=\u20091.33, 95% CI 1.07\u20131.65; OR<jats:sub>TT\/(CC\u2009+\u2009CT)<\/jats:sub>\u2009=\u20091.41, 95% CI 1.11\u20131.78; OR<jats:sub>(TT\u2009+\u2009CT)\/CC<\/jats:sub>\u2009=\u20091.36, 95% CI 1.11\u20131.66) and in an Asian population (OR<jats:sub>T\/C<\/jats:sub>\u2009=\u20091.80, 95% CI 1.24\u20132.62; OR<jats:sub>TT\/CC<\/jats:sub>\u2009=\u20092.13, 95% CI 1.27\u20133.57; OR<jats:sub>CT\/CC<\/jats:sub>\u2009=\u20091.93, 95% CI 1.37\u20132.71; OR<jats:sub>(TT\u2009+\u2009CT)\/CC<\/jats:sub>\u2009=\u20092.03, 95% CI 1.49\u20132.77). Negative associations of the A1298C polymorphism were only observed among Asian pregnant women (OR<jats:sub>C\/A<\/jats:sub>\u2009=\u20090.66, 95% CI 0.50\u20130.88; OR<jats:sub>CC\/AA<\/jats:sub>\u2009=\u20090.10, 95% CI 0.02\u20130.53; OR<jats:sub>CC\/(AA\u2009+\u2009AC)<\/jats:sub>\u2009=\u20090.11, 95% CI 0.02\u20130.57; OR<jats:sub>(CC\u2009+\u2009AC)\/AA<\/jats:sub>\u2009= 0.68, 95% CI 0.49\u20130.94).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\n<jats:italic>MTHFR<\/jats:italic> 677\u2009T may play a significant role in regard to the risk of preterm delivery, especially in the Asian population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13566","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T02:09:39Z","timestamp":1515550179000},"page":"663-672","source":"Crossref","is-referenced-by-count":4,"title":["Systematic review and meta\u2010analysis of the associations between maternal methylenetetrahydrofolate reductase polymorphisms and preterm delivery"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5895-442X","authenticated-orcid":false,"given":"Qiwen","family":"Fang","sequence":"first","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"},{"name":"Key Laboratory of Public Health Safety Fudan University, Ministry of Education  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"},{"name":"Key Laboratory of Public Health Safety Fudan University, Ministry of Education  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenqiu","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"},{"name":"Key Laboratory of Public Health Safety Fudan University, Ministry of Education  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"},{"name":"Key Laboratory of Public Health Safety Fudan University, Ministry of Education  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5187-7393","authenticated-orcid":false,"given":"Tiejun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Fudan University  Shanghai China"},{"name":"Key Laboratory of Public Health Safety Fudan University, Ministry of Education  Shanghai China"},{"name":"Collaborative Innovation Center of Social Risks Governance in Health Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-090810-182459"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60857-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.01.009"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2003.021634"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1006\/mgme.2000.3027"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.4.962"},{"key":"e_1_2_8_10_1","volume-title":"Hyperhomocysteinemia. 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