{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:28:12Z","timestamp":1740126492735,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T00:00:00Z","timestamp":1518566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the clinicopathologic and genetic correlations between double primary endometrial and colorectal cancer related to Lynch syndrome and to analyze germline mutations in mismatch repair genes in endometrial cancer patients in Korea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen patients diagnosed with pathologically endometrial and colorectal cancer between January 2005 and November 2016 in a single institution were enrolled in the study. The medical records were retrospectively analyzed. The genetic mutational information of endometrial cancer in Korea was retrieved from the literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Endometrial cancer was diagnosed first in eight (62%) patients, and one patient was diagnosed with colorectal cancer first. Endometrioid adenocarcinoma was reported in 10 of 13 (77%) endometrial cancer patients. Endometrial cancer was found at the low uterine segment in three patients. Three of four patients had high microsatellite instability. The loss of mismatch repair proteins was confirmed in 7 of 11 cases using immunohistochemistry. Four patients fulfilled clinical criteria based on a family history of cancer. Overall, the incidence of suspected Lynch syndrome was 77% (10\/13). Four of them underwent genetic testing and three were found to have a pathogenic germline mutation. A possible founder mutation, c.1757_1758insC in <jats:italic>MLH1,<\/jats:italic> was observed in 21 germline mutation information from literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study describes the clinicopathologic data of double primary endometrial and colorectal cancer patients and supports that these patients should undergo closed approach for Lynch syndrome. Moreover, a possible founder mutation in Korean endometrial cancer patients was identified.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13603","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T13:23:23Z","timestamp":1518614603000},"page":"944-950","source":"Crossref","is-referenced-by-count":3,"title":["Clinicopathologic characteristics of double primary endometrial and colorectal cancers in a single institution"],"prefix":"10.1111","volume":"44","author":[{"given":"Hyun J.","family":"Lee","sequence":"first","affiliation":[{"name":"Comprehensive Gynecologic Cancer Center, Department of Obstetrics and Gynecology, CHA Bundang Medical Center CHA University  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-6731","authenticated-orcid":false,"given":"Min C.","family":"Choi","sequence":"additional","affiliation":[{"name":"Comprehensive Gynecologic Cancer Center, Department of Obstetrics and Gynecology, CHA Bundang Medical Center CHA University  Seongnam Korea"},{"name":"Hereditary Gynecologic Cancer Clinic, Precision Medicine Center, CHA Bundang Medical Center CHA University  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja\u2010Hyun","family":"Jang","sequence":"additional","affiliation":[{"name":"GreenCross Laboratories  Yongin City Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang G.","family":"Jung","sequence":"additional","affiliation":[{"name":"Comprehensive Gynecologic Cancer Center, Department of Obstetrics and Gynecology, CHA Bundang Medical Center CHA University  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun","family":"Park","sequence":"additional","affiliation":[{"name":"Comprehensive Gynecologic Cancer Center, Department of Obstetrics and Gynecology, CHA Bundang Medical Center CHA University  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won D.","family":"Joo","sequence":"additional","affiliation":[{"name":"Comprehensive Gynecologic Cancer Center, Department of Obstetrics and Gynecology, CHA Bundang Medical Center CHA University  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Hereditary Gynecologic Cancer Clinic, Precision Medicine Center, CHA Bundang Medical Center CHA University  Seongnam Korea"},{"name":"Department of Pathology, CHA Bundang Medical Center CHA University  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chan","family":"Lee","sequence":"additional","affiliation":[{"name":"Comprehensive Gynecologic Cancer Center, Department of Obstetrics and Gynecology, CHA Bundang Medical Center CHA University  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Je H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Comprehensive Gynecologic Cancer Center, Department of Obstetrics and Gynecology, CHA Bundang Medical Center CHA University  Seongnam Korea"},{"name":"Hereditary Gynecologic Cancer Clinic, Precision Medicine Center, CHA Bundang Medical Center CHA University  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2013.24.4.298"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000466373.71146.51"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.14171"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.743"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.6296"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02552613"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70510-X"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh034"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003840100348"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22986"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyq144"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2015.58.2.112"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2015.07.018"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2003.13387.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327480901600103"},{"key":"e_1_2_6_17_1","first-page":"38","article-title":"Mutational analysis of promoters of mismatch repair genes hMSH2 and hMLH1 in hereditary nonpolyposis colorectal cancer and early onset colorectal cancer patients: Identification of three novel germ\u2010line mutations in promoter of the hMSH2 gene","volume":"62","author":"Shin KH","year":"2002","journal-title":"Cancer Res"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.6118\/jmm.2013.19.3.143"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.5468\/KJOG.2012.55.11.870"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.2.237"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.9277"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02235756"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.5468\/ogs.2013.56.6.408"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000154885.44002.ae"},{"key":"e_1_2_6_25_1","first-page":"370","volume-title":"Pathology of the Female Reproductive Tract","author":"Mutter GL","year":"2014"},{"key":"e_1_2_6_26_1","first-page":"413","article-title":"ACOG practice bulletin, clinical management guidelines for obstetrician\u2010gynecologists, number 65, August 2005: Management of endometrial cancer","volume":"106","author":"American College of Obstetricians and Gynecologists","year":"2005","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.2596"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21560"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAP.0b013e31825c6b76"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.6118\/jmm.2017.23.1.69"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13603","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:38:51Z","timestamp":1695494331000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,14]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["10.1111\/jog.13603"],"URL":"https:\/\/doi.org\/10.1111\/jog.13603","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"type":"print","value":"1341-8076"},{"type":"electronic","value":"1447-0756"}],"subject":[],"published":{"date-parts":[[2018,2,14]]}}}