{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T13:06:03Z","timestamp":1782392763410,"version":"3.54.5"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Many women need estrogen therapy because of menopausal complaints. It is suggested that pomegranate plant has estrogenic effect. Aim of the study was to examine the effects of pomegranate seed extract on menopausal changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was conducted in an experimental environment with 23 Wistar Albino genus female rats. Sixteen rats were divided into two groups after ovariectomy. One group (SG) was fed with standard food and the pomegranate extract was added to drinking water of the other group (PG). Seven rats were identified as the sham group for the detection of basal values. At the end of 90 days, follicle stimulating hormone (FSH), estradiol, total cholesterol, high\u2010density lipoprotein cholesterol (HDL)\u2010cholesterol, low\u2010density lipoprotein cholesterol (LDL)\u2010cholesterol, triglyceride, tibial bone cortex thickness and vaginal epithelium thickness of the groups were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FSH, total\u2010cholesterol and HDL\u2010cholesterol levels were similar among the three groups (<jats:italic>P<\/jats:italic> &gt; 0.05), while others were different (<jats:italic>P<\/jats:italic> &lt; 0.05). In binary comparisons (PG vs SG), estradiol level (average \u00b1 standard deviation [SD]: 252 \u00b1 43 vs 154 \u00b1 26 pg\/mL), tibial bone cortex thickness (58 \u00b1 7 vs 40 \u00b1 2 \u03bcm) and vaginal epithelium thickness (21 \u00b1 7 vs 10 \u00b1 4 \u03bcm) were significantly higher in PG. In PG, triglyceride levels (103 \u00b1 26 vs 87 \u00b1 41 mg\/dL) were higher and LDL\u2010cholesterol levels were lower (20 \u00b1 8 vs 27 \u00b1 8 mg\/dL), but these differences were not significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In rats fed with pomegranate extract, estradiol levels increased and tibial bone cortex thickness and vaginal epithelium thickness also increased. Pomegranate itself or its formulation extracts may be a support or an alternative to the main treatment modalities in the preservation of bone density and the treatment of vaginal epithelial atrophy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13642","type":"journal-article","created":{"date-parts":[[2018,3,31]],"date-time":"2018-03-31T00:01:31Z","timestamp":1522454491000},"page":"1087-1091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of pomegranate extract on vagina, skeleton, metabolic and endocrine profiles in an ovariectomized rat model"],"prefix":"10.1111","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-0513","authenticated-orcid":false,"given":"Isik","family":"Kaban","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology, Istanbul Education and Research Hospital University of Health Sciences  Istanbul 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