{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T10:54:50Z","timestamp":1774263290391,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Department of Scientific Research Centre's funding scheme","award":["201610570030"],"award-info":[{"award-number":["201610570030"]}]},{"name":"Scientific Research Centre's funding scheme","award":["2014JDA028"],"award-info":[{"award-number":["2014JDA028"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to investigate the safety and efficacy of low\u2010dose mifepristone combined with self\u2010administered misoprostol for termination of early pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 533 women seeking medical abortion in early pregnancy (\u226449 days since the last menstrual period) were divided randomly into hospital\u2010 (H\u2010Mis, 250) and self\u2010 (S\u2010Mis, 283) administered misoprostol groups. Women in two groups took 100 mg of oral mifepristone in hospital followed by 200 \u03bcg of sublingual misoprostol 24 h later in hospital or home. The primary outcome parameter was complete abortion without surgical intervention. Secondary outcomes were uterine bleeding, return of regular menses, side effects and patient acceptability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>High rates of complete abortion were observed for both the H\u2010Mis group (243\/250; 94.8%) and the S\u2010Mis group (266\/283; 94.0%). No significant differences in outcomes (complete abortion\/failure rates) or side effects were observed between the two groups. General satisfaction rates were similar for the two groups (H\u2010Mis, 231\/250, 92.4%; S\u2010Mis, 263\/283, 92.9%; <jats:italic>P<\/jats:italic> &gt; 0.05). Higher convenience of administration (H\u2010Mis, 211\/250, 84.4%; S\u2010Mis, 270\/283, 95.4%; <jats:italic>P<\/jats:italic> &lt; 0.05) and privacy protection (H\u2010Mis, 214\/250, 85.6%; S\u2010Mis, 267\/283, 94.3%; <jats:italic>P<\/jats:italic> &lt; 0.05) satisfaction rates were obtained for the S\u2010Mis group than for the H\u2010Mis group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Self\u2010administered sublingual misoprostol is as safe and effective as hospital\u2010administered misoprostol following low\u2010dose mifepristone to terminate early pregnancy (\u226449 days of amenorrhoea) with fewer side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13716","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T09:06:48Z","timestamp":1530781608000},"page":"1705-1711","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Early medical abortion with self\u2010administered low\u2010dose mifepristone in combination with misoprostol"],"prefix":"10.1111","volume":"44","author":[{"given":"Li\u2010Ping","family":"Song","sequence":"first","affiliation":[{"name":"Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory for Reproduction and Genetics of Guangdong Higher\u2010Education Institutes, Guangzhou Institute of Obstetrics and Gynecology Third Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shi\u2010Yan","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory for Reproduction and Genetics of Guangdong Higher\u2010Education Institutes, Guangzhou Institute of Obstetrics and Gynecology Third Affiliated Hospital, Guangzhou Medical University  Guangzhou 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