{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T08:30:39Z","timestamp":1777537839218,"version":"3.51.4"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T00:00:00Z","timestamp":1530748800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amniotic fluid embolism (AFE) causes consumption coagulopathy, which requires a massive transfusion to save the mother's life. The preparation of such a massive transfusion is too time\u2010consuming in extremely emergent clinical settings and occasionally leads to devastating side effects such as transfusion\u2010associated acute lung injury. C1 esterase inhibitor (C1INH) is a protein with the ability to inhibit complement, coagulation and kinin pathways. The C1INH concentration in AFE patients is low, and it has been speculated that the administration of C1INH concentrate could have a striking and beneficial effect on AFE patients in critical condition by ameliorating their perturbed coagulation system. We report the case of a 32\u2010year\u2010old Japanese AFE patient in whom deteriorated vital signs and coagulopathy recovered within minutes after an injection of C1INH concentrate. C1INH concentrate can quickly revive the deteriorated vital signs and the atonic uterus that stem from AFE and may reduce the total amount of transfusion.<\/jats:p>","DOI":"10.1111\/jog.13717","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T09:22:43Z","timestamp":1530782563000},"page":"1995-1998","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Practical use of C1 esterase inhibitor concentrate for clinical amniotic fluid embolism"],"prefix":"10.1111","volume":"44","author":[{"given":"Miki","family":"Akasaka","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Japanese Red Cross Ise Hospital  Ise Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Osato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mie University Hospital  Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mito","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Japanese Red Cross Ise Hospital  Ise Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohisa","family":"Kihira","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Japanese Red Cross Ise Hospital  Ise Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mie University Hospital  Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaharu","family":"Yamawaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Japanese Red Cross Ise Hospital  Ise Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,5]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2010.01319.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-010304"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0041-1132.2004.04347.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)91474-9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12428"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000107"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000217"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.316"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02313.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X13513578"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(00)01213-8"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13717","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13717","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T08:19:25Z","timestamp":1694852365000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,5]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/jog.13717"],"URL":"https:\/\/doi.org\/10.1111\/jog.13717","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,5]]},"assertion":[{"value":"2018-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-06-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}