{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:17:40Z","timestamp":1776259060836,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T00:00:00Z","timestamp":1531785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008883","name":"Nagoya City University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008883","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The purpose of this study was to describe the characteristics of women with twin pregnancies who undergo noninvasive prenatal testing (NIPT) as well as the post\u2010partum and neonatal outcomes of such cases in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population consisted of women who were pregnant with twins and who underwent NIPT using massively parallel sequencing (MPS) at Nagoya City University Hospital between April 2013 and June 2016. Questionnaires were completed pre\u2010NIPT and post\u2010partum.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 4009 women who underwent NIPT during the study period, 75 women (1.9%) were pregnant with twins. Fifteen women (20%) experienced vanishing twin\/intrauterine fetal deaths at &lt;22\u2009weeks, and 60 women (80%) had normal twin pregnancies at the time of genetic counseling for NIPT. The use of NIPT was correlated with increased proportions of women using assisted reproductive technology (ART). The test had a high performance, with a false\u2010positive rate of 1.7% and no false negatives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, NIPT had a high performance, with a false positive rate of 1.7% and no false negatives. When treating women with twin pregnancies, the efficacy of NIPT should be explained during genetic counseling. Further larger studies are required to assess the reliability and validity of NIPT in twin pregnancies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13744","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T11:14:16Z","timestamp":1531826056000},"page":"1909-1914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Performance and outcomes of noninvasive prenatal testing for twin pregnancies in Japan"],"prefix":"10.1111","volume":"44","author":[{"given":"Eri","family":"Takeda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"},{"name":"Department of Genetic Counseling, Graduate School of Humanities and Sciences Ochanomizu University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Suzumori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saki","family":"Inuzuka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Oseto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Ohigashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Yotsumoto","sequence":"additional","affiliation":[{"name":"Department of Genetic Counseling, Graduate School of Humanities and Sciences Ochanomizu University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehiko","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Genetic Counseling, Graduate School of Humanities and Sciences Ochanomizu University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Sugiura\u2010Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/sper.2002.34775"},{"key":"e_1_2_7_3_1","volume-title":"Vital Statistics 2016","author":"Statistics and Information Department","year":"2017"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2011.73"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356495"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.3892"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.14690"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4132"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.97"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4608"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001051"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4539"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm3030679"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4837"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4303"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15964"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.02.009"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088484"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/jhg.2016.25"},{"key":"e_1_2_7_20_1","unstructured":"The Japan Society of Obstetrics and Gynecology. 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