{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T21:20:42Z","timestamp":1776720042692,"version":"3.51.2"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology, Japan","doi-asserted-by":"crossref","award":["S1311029"],"award-info":[{"award-number":["S1311029"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology, Japan","doi-asserted-by":"crossref","award":["17K11247"],"award-info":[{"award-number":["17K11247"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare serum levels of angiogenesis\u2010related factors between 14 women with HELLP (hemolysis, elevated liver enzymes and low platelet count) syndrome and a woman with acute fatty liver of pregnancy (AFLP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serum samples were collected in 2004\u20132008 and 2013\u20132016. The levels of soluble fms\u2010like tyrosine kinase 1 (sFlt\u20101) and placental growth factor (PlGF) were measured by an automated electrochemiluminescence immunoassay using Elecsys sFlt\u20101 and Elecsys PlGF. After logarithmic transformation, levels of sFlt\u20101, PlGF and the sFlt\u20101\/PlGF ratio in a woman with AFLP were compared with those in women with HELLP syndrome, using the one\u2010sample <jats:italic>t<\/jats:italic>\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 37\u2009weeks of gestation, a patient was diagnosed with AFLP based on Swansea criteria (showing six features including elevated transaminases), and she also showed a duodenal ulcer with active bleeding, thrombocytopenia and hypertension. Her serum levels of sFlt\u20101 and sFlt\u20101\/PlGF ratio were significantly higher than in those with HELLP syndrome (273\u2009040\u2009pg\/mL vs 15\u2009135 [mean], <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; 4236 vs 224, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001; respectively). However, her serum level of PlGF was not significantly different from those with HELLP syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Serum levels of sFlt\u20101 and the sFlt\u20101\/PlGF ratio, but not PlGF, in a woman with AFLP were markedly higher than those in women with HELLP syndrome. AFLP may be a different clinical entity from HELLP syndrome based on angiogenesis\u2010related factors. Clinically, the sFlt\u20101\/PlGF ratio may be used to rapidly distinguish AFLP from HELLP syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13786","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T03:15:21Z","timestamp":1535080521000},"page":"96-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Markedly higher sFlt\u20101\/PlGF ratio in a woman with acute fatty liver of pregnancy compared with HELLP syndrome"],"prefix":"10.1111","volume":"45","author":[{"given":"Hirotada","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University School of Medicine  Tochigi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiho","family":"Nagayama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Jichi Medical University School of Medicine  Tochigi 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