{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:12:00Z","timestamp":1775027520735,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We sought to examine the safety and efficacy of a 52\u2010mg levonorgestrel\u2010releasing intrauterine system (LNG\u2010IUS), and to evaluate the changes in biomarkers of infection, anemia and cardiovascular conditions after LNG\u2010IUS insertion in women with cardiovascular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively followed women with a cardiovascular disease in whom a 52\u2010mg LNG\u2010IUS was inserted between 2009 and 2015. The primary outcome was the frequency of cardiovascular and gynecologic side effects due to the LNG\u2010IUS over the year after LNG\u2010IUS insertion. The secondary outcomes were the changes in menstrual blood loss and biomarkers, e.g., white blood cell count and the levels of C\u2010reactive protein, hemoglobin and brain natriuretic peptide. We also evaluated the 24\u2010month continuation rate of LNG\u2010IUS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 34 women were prospectively followed\u2010up, including two women with pulmonary hypertension. No cardiovascular side effects were identified during the 1\u2009year after LNG\u2010IUS insertion, other than one case of mild vasovagal reaction at insertion. Neither the white blood cell count nor the C\u2010reactive protein value increased after LNG\u2010IUS insertion. The menstrual blood loss was decreased in most subjects and the median hemoglobin levels increased significantly within 1\u2009year after insertion (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>P<\/jats:italic>\u2009=\u20090.002). Moreover, brain natriuretic peptide levels tended to decrease in correspondence with the hemoglobin elevation (<jats:italic>P<\/jats:italic>\u2009=\u20090.074). The 24\u2010month LNG\u2010IUS continuation rate was 97% (95% confidence interval 85\u2013100).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No clinically significant cardiovascular event was identified during the 1\u2009year after 52\u2010mg LNG\u2010IUS insertion among women with cardiovascular disease. The 52\u2010mg LNG\u2010IUS may have specific favorable effects by decreasing the risk of iron deficiency anemia in these women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13828","type":"journal-article","created":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T08:40:33Z","timestamp":1538037633000},"page":"382-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Safety and efficacy of a 52\u2010mg levonorgestrel\u2010releasing intrauterine system in women with cardiovascular disease"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6442-3748","authenticated-orcid":false,"given":"Yusuke","family":"Ueda","sequence":"first","affiliation":[{"name":"Department of Perinatology and Gynecology National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chizuko A.","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Perinatology and Gynecology National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chinami","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Department of Perinatology and Gynecology National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takekazu","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Department of Perinatology and Gynecology National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoichi","family":"Hazama","sequence":"additional","affiliation":[{"name":"Department of Perinatology and Gynecology National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Tsuritani","sequence":"additional","affiliation":[{"name":"Department of Perinatology and Gynecology National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Iwanaga","sequence":"additional","affiliation":[{"name":"Department of Perinatology and Gynecology National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reiko","family":"Neki","sequence":"additional","affiliation":[{"name":"Department of Perinatology and Gynecology National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Mie University Faculty of Medicine  Tsu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yoshimatsu","sequence":"additional","affiliation":[{"name":"Department of Perinatology and Gynecology National Cerebral and Cardiovascular Center  Suita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182a91f45"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1110855"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31821188ad"},{"key":"e_1_2_6_5_1","unstructured":"United Nations. 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