{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T06:35:21Z","timestamp":1781073321080,"version":"3.54.1"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T00:00:00Z","timestamp":1543881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Recently, it is widely recognized that positivity for anti\u2010phospholipid antibodies is a causative factor for a range of reproductive failures. Anti\u2010cardiolipin beta2 glycoprotein I antibody (anti\u2010CL\u2010beta2\u2010GPI) is a representative anti\u2010phospholipid antibody, which strongly correlates with the development of thrombotic events and diversity of adverse pregnancies. In this series, we aimed to elucidate effective treatment for patients with recurrent fetal losses positive for anti\u2010CL\u2010beta2\u2010GPI using Japanese\u2010modified Chinese herbal medicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010one patients with recurrent fetal losses who were positive for anti\u2010CL\u2010beta2\u2010GPI were treated with the Japanese\u2010modified Chinese herbal medicine, Sairei\u2010to (Chai\u2010ling\u2010tang), and low\u2010dose aspirin with or without adrenal corticosteroid hormone. Of the 21 patients, the value of anti\u2010CL\u2010beta2\u2010GPI ranged from 1.9 to 3.4 in 10 patients, and it was over 3.5 in 11 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 21 patients treated with the current protocol, the pregnancy successfully continued in 17 patients (success rate: 81.0%). Of the four patients who showed repeated abortion, chromosome abnormality of chorionic villi was observed in two; thus, the success rate would be 89.5% (17 of 19 cases) on excluding these cases from the evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The efficacy of the current treatment adopting the modified Japanese version of the Chinese herbal medicine Sairei\u2010to for patients with recurrent fetal losses positive for anti\u2010CL\u2010beta2\u2010GPI was indicated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13871","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T04:49:42Z","timestamp":1543985382000},"page":"549-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment for patients with recurrent fetal losses positive for anti\u2010cardiolipin beta2 glycoprotein I antibody using Sairei\u2010to (Chai\u2010ling\u2010tang) and 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