{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:22:48Z","timestamp":1792290168173,"version":"4.4.0"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human cytomegalovirus (CMV) is a common cause of congenital infection that may lead to severe long\u2010term sequelae. Because there are no established vaccines, fetal interventions or neonatal treatments, neither maternal nor neonatal screening is recommended. However, recent studies have indicated that early antiviral treatment may improve neurological outcomes in symptomatic infants with congenital infection. Therefore, prenatal detection may be important in newborns at high risk of such infection. Polymerase chain reaction for CMV DNA in the amniotic fluid is considered the gold standard for diagnosis of intrauterine infection, but its use is limited because amniocentesis is an invasive procedure. In a prospective cohort study, we have reported that the presence of CMV DNA in secretions of the maternal uterine cervix were predictive of congenital infection in groups at high risk. However, we also recently demonstrated that maternal serological screening for primary CMV infection using specific immunoglobulin G, the immunoglobulin G avidity index or specific immunoglobulin M can overlook many cases. Previous research has indicated that the combination of early detection by universal neonatal screening of urinary CMV DNA combined with early antiviral therapy can improve outcomes in infants with symptomatic congenital infection. In this article, we review the current state of maternal and neonatal screening for congenital CMV infection.<\/jats:p>","DOI":"10.1111\/jog.13889","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T23:55:18Z","timestamp":1545954918000},"page":"514-521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Maternal and neonatal screening methods for congenital cytomegalovirus infection"],"prefix":"10.1111","volume":"45","author":[{"given":"Kenji","family":"Tanimura","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kobe University Graduate School of Medicine  Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.15.4.680-715.2002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.Supplement_7.S745"},{"key":"e_1_2_8_4_1","first-page":"82","article-title":"Cytomegalovirus infection: Congenital and neonatal disease","volume":"80","author":"Peckham CS","year":"1991","journal-title":"Scand J Infect Dis Suppl"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198511143132006"},{"key":"e_1_2_8_6_1","volume-title":"Vaccines for the 21st Century: A Tool for Decision making","author":"Stratton KR","year":"2000"},{"key":"e_1_2_8_7_1","first-page":"35","article-title":"Surveillance of congenital cytomegalovirus disease, 1990\u20131991. Collaborating Registry Group","volume":"41","author":"Dobbins JG","year":"1992","journal-title":"MMWR Surveill Summ"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-017-0358-8"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(03)00192-6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2009.08.012"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2015.08.003"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199203053261003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.12.012"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/145.2.647"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03564.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02172-08"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23387"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2013-0333"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2015.03.002"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix621"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00657-2"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.107110"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.106347"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)34480-2"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw707"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000321346"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sult.2015.04.001"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2017.09.006"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2017.1279344"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00062-12"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2018.04.010"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pix105"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2013.12.007"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13889","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T05:33:15Z","timestamp":1705555995000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,27]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/jog.13889"],"URL":"https:\/\/doi.org\/10.1111\/jog.13889","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,27]]},"assertion":[{"value":"2018-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}