{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T14:27:09Z","timestamp":1780496829098,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T00:00:00Z","timestamp":1548547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The optimal antibiotic regimen for preterm premature rupture of membrane (pPROM) is still unclear. This study aimed to determine the effects of ampicillin\u2013sulbactam (SBT\/ABPC) and azithromycin (AZM) on the incidence of bronchopulmonary dysplasia (BPD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included women with singleton gestations and a diagnosis of pPROM between 22 and 27\u2009weeks of gestation. In patients presenting with a high risk of intra\u2010amniotic infection between January 2011 and May 2013, piperacillin or cefmetazole + clindamycin (regimen 1 group; <jats:italic>n<\/jats:italic>\u2009=\u200911) was administered, whereas SBT\/ABPC and AZM (regimen 2 group; <jats:italic>n<\/jats:italic>\u2009=\u200911) were administered in patients presenting a similar risk between June 2013 and May 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The incidence of moderate or severe infant BPD in the regimen 2 group was significantly lower than that in the regimen 1 group, even when adjusted for gestational age at the time of rupture of membrane, with an odds ratio (95% confidence interval) of 0.02 (1.8\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>\u20130.33). The incidence of BPD and total days on mechanical ventilation were significantly lower in the regimen 2 group than in the regimen 1 group. No significant differences were seen in other morbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with pPROM between 22 and 27\u2009weeks of gestation, the administration of SBT\/ABPC and AZM may improve the perinatal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13903","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T05:39:29Z","timestamp":1548653969000},"page":"967-973","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["New antibiotic regimen for preterm premature rupture of membrane reduces the incidence of bronchopulmonary dysplasia"],"prefix":"10.1111","volume":"45","author":[{"given":"Satoko","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology National Hospital Organization, Saga Hospital  Saga Japan"},{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine 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