{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:50:16Z","timestamp":1760907016418},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>It is difficult to prenatally identify 5p deletion (\u2212) syndrome. Here, we report five cases of 5p\u2010 syndrome diagnosed by invasive prenatal diagnosis. Of them, three had a small cerebellum in the second trimester. In one case, a prominent renal pelvis and an absent nasal bone were also found in the first trimester. However, there were no abnormal ultrasound findings in the other two cases. Two cases had noninvasive prenatal testing and one showed a \u20185p\u2010 syndrome positive result\u2019 because of reduced amount of cell\u2010free DNA in 5p. Two had combined first\u2010trimester screening performed where one had a high\u2010risk result for trisomy 18 and a low pregnancy\u2010associated plasma protein\u2010A level. Two cases of 5p\u2010 syndrome resulted from a parental balanced translocation. Prenatal diagnosis will only be made on invasive prenatal diagnosis for abnormal ultrasound findings with small cerebellum, abnormal prenatal screening or a parental reciprocal translocation involving 5p.<\/jats:p>","DOI":"10.1111\/jog.13911","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T11:51:44Z","timestamp":1554119504000},"page":"923-926","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prenatal diagnosis of 5p deletion syndrome: Report of five cases"],"prefix":"10.1111","volume":"45","author":[{"given":"Annisa S. L.","family":"Mak","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Queen Elizabeth Hospital  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa W. L.","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Queen Elizabeth Hospital  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelvin Y. K.","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Queen Mary Hospital The University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita S. Y.","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Queen Mary Hospital The University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary H. Y.","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Queen Mary Hospital The University of Hong Kong  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwok Y.","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Queen Elizabeth Hospital  Hong Kong SAR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.2.295"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2012.704452"},{"key":"e_1_2_5_4_1","first-page":"e181","article-title":"Prenatal diagnosis of Cri\u2010du\u2010Chat syndrome: Importance of ultrasonographical markers","volume":"50","author":"Teoh XH","year":"2009","journal-title":"Singapore Med J"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-1-33"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(1998100)18:10<1099::AID-PD400>3.0.CO;2-H"},{"key":"e_1_2_5_7_1","first-page":"101","article-title":"Cri\u2010du\u2010Chat syndrome: clinical profile and prenatal diagnosis","volume":"44","author":"Tullu MS","year":"1998","journal-title":"J Postgrad Med"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1130"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2006.25.3.387"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.03.003"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.5734\/JGM.2017.14.1.34"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.13270"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18979"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.10.005"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.11.041"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13911","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.13911","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T18:36:53Z","timestamp":1694371013000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/jog.13911"],"URL":"https:\/\/doi.org\/10.1111\/jog.13911","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"2018-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}