{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T13:58:32Z","timestamp":1760623112169},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate various adverse symptoms during short\u2010term use of ulipristal acetate in women with uterine myomas (<jats:italic>n<\/jats:italic>\u2009=\u200990), adenomyosis (<jats:italic>n<\/jats:italic>\u2009=\u20093) or both (<jats:italic>n<\/jats:italic>\u2009=\u20097).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One hundred premenopausal women who received ulipristal acetate for 4\u201312\u2009weeks during 2016 to 2017 were selected. The medical records were reviewed and the following information was collected; adverse symptoms during medication, presence of menorrhagia or menstrual cramps, blood hemoglobin and liver function test. Adverse symptoms were recorded in the medical records as a checklist form including 76 specific progestin\u2010related symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, the most frequent adverse symptom was amenorrhea (43%), followed by weight gain (29%), fatigue (27%), abdominal discomfort (21%), decreased menstrual flow (19%) and dizziness (18%). In 89 symptomatic women (with heavy menstrual bleeding and\/or menstrual cramping pain and\/or anemia), the most frequent adverse symptom was weight gain (27%) and fatigue (27%), followed by abdominal discomfort (21%), dry eye (18%), facial flushing (17%), dizziness (17%), headache (17%) and increased vaginal discharge (15%). Fourteen women stopped the medication due to unwanted adverse symptoms. Of this discontinuation group, major complaint was fatigue (50%), followed by weight gain (36%) and breast discomfort (35.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adverse symptoms were common and discontinuation rate was somewhat higher during short\u2010term course of ulipristal acetate. Information about incidence of various adverse symptoms should be given to women who willing to take ulipristal acetate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13917","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T21:25:29Z","timestamp":1548365129000},"page":"865-870","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Adverse symptoms during short\u2010term use of ulipristal acetate in women with uterine myomas and\/or adenomyosis"],"prefix":"10.1111","volume":"45","author":[{"given":"Yeon Hee","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Jin","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Hospital  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Bundang Hospital  Seongnam Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seul Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Bundang Hospital  Seongnam Korea"},{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Chul","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Bundang Hospital  Seongnam Korea"},{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728214.2018.1446943"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-1225"},{"key":"e_1_2_7_4_1","first-page":"285","article-title":"Ulipristal acetate: A novel pharmacological approach for the treatment of uterine fibroids","volume":"8","author":"Biglia N","year":"2014","journal-title":"Drug Des Devel Ther"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2017.10.008"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2017.1372174"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181705d0e"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.09.059"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103182"},{"key":"e_1_2_7_10_1","first-page":"321","article-title":"Clinical utility of ulipristal acetate for the treatment of uterine fibroids: Current evidence","volume":"7","author":"Bourdet AT","year":"2015","journal-title":"Int J Women's Health"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2018.04.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103180"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.10.038"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2008.19"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmm023"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e318251035b"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002462"},{"key":"e_1_2_7_18_1","unstructured":"European Medicines Agency Esmya: new measures to minimise risk of rare but serious liver injury. [Cited 1 Jun 2018.] Available from URL: (http:\/\/www.ema.europa.eu\/ema\/index.jsp?curl=pages\/medicines\/human\/referrals\/Esmya\/human_referral_prac_000070.jsp&mid=WC0b01ac05805c516f)"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.13917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.13917","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.13917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T18:36:25Z","timestamp":1694370985000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.13917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,24]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["10.1111\/jog.13917"],"URL":"https:\/\/doi.org\/10.1111\/jog.13917","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,24]]},"assertion":[{"value":"2018-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}