{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:20:30Z","timestamp":1785547230534,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,20]],"date-time":"2019-01-20T00:00:00Z","timestamp":1547942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the effect of vaginal tablet of <jats:styled-content style=\"fixed-case\"><jats:italic>Salvia officinalis<\/jats:italic><\/jats:styled-content>, alone and in combination with Clotrimazole, on the recovery of Vulvovaginal candidiasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this triple\u2010blind randomized controlled trial, 111 participants were randomly assigned into three groups of 37 patients using block randomization with block sizes of 6 and 9, and allocation ratio of 1:1:1: 100\u2009mg vaginal tablet of Clotrimazole and Placebo (CP), 400\u2009mg vaginal tablet of <jats:styled-content style=\"fixed-case\"><jats:italic>S. officinalis<\/jats:italic><\/jats:styled-content> and Placebo (SP), and vaginal tablet of <jats:styled-content style=\"fixed-case\"><jats:italic>S. officinalis<\/jats:italic><\/jats:styled-content> and Clotrimazole (SC), once daily for 7\u2009days. On the seventh day after the treatment was ended up, Vulvovaginal candidiasis were examined by vaginal symptoms and wet test, and if positive, they were examined by culture in chrome agar Candida medium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Socio\u2010demographic characteristics was similar (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Thirty\u2010six, 36 and 35 patients, respectively in CP, SC and SP groups recruited in the study. The frequency of a positive wet test confirmed by Sabrodextrose agar medium 7\u2009days after treatment was significantly lower in SC group than the reference group of CP (adjusted odds ratio\u2009=\u20090.09, 95% confidence interval: 0.93\u20130.932, <jats:italic>P<\/jats:italic>\u2009=\u20090.043). There was no significant difference between SP and CP group (<jats:italic>P<\/jats:italic>\u2009=\u20090.071, 95% confidence interval: 0.032\u20131.151, adjusted odds ratio\u2009=\u20090.192). Also, there was no significant difference between the three groups in terms of vaginal symptoms at the baseline (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05), however the statistical differences were indicated after the intervention in cheesy discharge, pruritus and Vulvovaginal edema (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05.(.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>\n<jats:styled-content style=\"fixed-case\"><jats:italic>S. officinalis<\/jats:italic><\/jats:styled-content> in the form of vaginal tablet, alone and when combined with Clotrimazole, can treat the Vulvovaginal Candidiasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13918","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T01:43:55Z","timestamp":1548035035000},"page":"897-907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Comparing the effectiveness of <scp><i>Salvia officinalis<\/i><\/scp>, clotrimazole and their combination on vulvovaginal candidiasis: A randomized, controlled clinical trial"],"prefix":"10.1111","volume":"45","author":[{"given":"Fatemeh","family":"Ahangari","sequence":"first","affiliation":[{"name":"Department of Midwifery, Students' Research Committee, Nursing and Midwifery Faculty Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azizeh","family":"Farshbaf\u2010Khalili","sequence":"additional","affiliation":[{"name":"Aging Research Institute, Physical Medicine and rehabilitation Research Center Tabriz University of Medical Science  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousef","family":"Javadzadeh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics Tabriz University of Medical Sciences, Faculty of Pharmacy  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Adibpour","sequence":"additional","affiliation":[{"name":"Department of Parasitology Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnaz","family":"Sadeghzadeh Oskouei","sequence":"additional","affiliation":[{"name":"Department of Midwifery Tabriz University of Medical Science  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.9.3.335"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.06.067"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60917-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl246"},{"key":"e_1_2_7_6_1","first-page":"62","article-title":"Prevalence of vaginitis in Iranian women symptoms and clinical association","volume":"22","author":"Tehrani R","year":"2012","journal-title":"Med Sci J Islamic Azad Univ Tehran Med Branch"},{"key":"e_1_2_7_7_1","first-page":"67","article-title":"Prevalence and risk factors for candidiasis infection in women referring to health centers of Tabriz","volume":"15","author":"Namazi A","year":"2008","journal-title":"J Med Sci Health Services Shahid Sadoughi Yazd"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.11.027"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir694"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.5005\/jp\/books\/10282_59","volume-title":"Antimicrobial drugs. 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