{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:58:52Z","timestamp":1790485132938,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T00:00:00Z","timestamp":1555977600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Natural Science Funding","award":["81673130"],"award-info":[{"award-number":["81673130"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study the molecular mechanism of G protein\u2010coupled receptor 30\u2010epidermal growth factor receptor (GPR30\u2010EGFR) signaling pathway on the proliferation of leiomyoma cells exposed with bisphenol A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Primary cultures and subcultures of human uterine leiomyoma (UL) cells. The expressions of messenger RNA and proteins of GPR30 and EGFR in 15 leiomyoma tissue specimens and all groups were detected by real\u2010time quantitative polymerase chain reaction assay and Western blot assay. The protein of mitogen\u2010activated protein kinases (MAPK)\/extracellular signal\u2013regulated kinases (ERK)\/c\u2010fos signaling pathway members was detected by Western blot assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bisphenol A promoted the growth of UL cells and the expressions of GPR30, EGFR, c\u2010fos and p\u2010ERK1\/2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bisphenol A was found to be a promoter specifically to proliferate the human UL cells by activating the transcription and translation of GPR30\u2010EGFR and MAPK\/ERK\/c\u2010fos signaling pathway members.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13972","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T04:49:41Z","timestamp":1556081381000},"page":"1277-1285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Bisphenol A promotes the 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