{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:54:00Z","timestamp":1774958040297,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T00:00:00Z","timestamp":1558828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571460"],"award-info":[{"award-number":["81571460"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To explore the impact of epidural analgesia on maternal and neonatal outcomes, especially the relation between epidural analgesia and intrapartum fever.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was conducted in a tertiary hospital for all deliveries from November 2017 to December 2017. A total of 506 women were divided into epidural and non\u2010epidural group by whether to receive analgesia or not. Univariate and multivariate analyses were performed with <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05 as significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Epidural analgesia was associated with higher risk of maternal intrapartum fever (relative risk [RR]\u2009=\u20093.28, 95% confidence interval, 1.55\u20136.95), more intravenous use of antibiotics (36.66% vs 17.04%, <jats:italic>P<\/jats:italic>&lt;0.001), longer time of second stage (58.55\u2009\u00b1\u200933.75 vs 47.39\u2009\u00b1\u200928.36\u2009min\uff0c<jats:italic>P<\/jats:italic>\u2009=\u20090.001) and longer total duration of labor (790.32\u2009\u00b1\u2009433.71 vs 461.33\u2009\u00b1\u2009270.39\u2009min\uff0c<jats:italic>P<\/jats:italic>&lt;0.001), but had no influence on mode of delivery, the amount of post\u2010partum hemorrhage or hospital stay after delivery and all the neonatal outcomes we studied. Further time effect analysis found that epidural analgesia less than 6\u2009h did not increase the risk of intrapartum fever (RR\u2009=\u20091.73, <jats:italic>P<\/jats:italic>\u2009=\u20090.15), however, when epidural analgesia lasted over 6\u2009h, it significantly increased the risk of fever (RR\u2009=\u20095.23, <jats:italic>P<\/jats:italic>&lt;0.001) but did not increase more adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Having epidural anesthesia 6\u2009h or more increases the risk of developing fever, but the prognosis of mothers and children is less affected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13988","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T03:45:09Z","timestamp":1558928709000},"page":"1435-1441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["A cohort study of the impact of epidural analgesia on maternal and neonatal outcomes"],"prefix":"10.1111","volume":"45","author":[{"given":"Huifen","family":"Yin","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University  Shanghai 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