{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:23:30Z","timestamp":1790666610755,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the Ministry of Health, Czech Republic, Conceptual Development of Research Organization, Motol University Hospital, Prague, Czech Republic Funding","award":["00064203"],"award-info":[{"award-number":["00064203"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To describe our first clinical pregnancy following a uterus transplant from a brain\u2010dead donor and to discuss current issues with deceased donor uterus transplantation as they relate to obstetrical success.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In August 2016, a 26\u2010year\u2010old woman with Mayer\u2013Rokitansky\u2013K\u00fcster\u2013Hauser syndrome was the fourth person worldwide to receive a uterine transplant from a deceased donor and was the second in our trial. in vitro fertilization treatments using the long gonadotropin\u2010releasing hormone agonist protocol preceded the transplantation procedure. Frozen embryo transfers were performed in months 12, 13, 16, 19 and 23 after transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recovery of the uterus of a 24\u2010year\u2010old brain\u2010dead nulliparous donor and the transplant procedure itself was uncomplicated. No abnormalities were revealed on Pap smears, which were performed every 6\u2009months during the post\u2010transplant period, and cervical biopsies showed no epithelial dysplasia. The fifth frozen embryo transfer resulted in a clinical pregnancy. Three weeks after embryo transfer, an intrauterine gestational sac containing an embryo with a heartbeat was detected. One week later, signs of a missed abortion were revealed by ultrasound. Two weeks later, spontaneous bleeding occurred, and an ultrasound examination performed a week later confirmed an empty uterine cavity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In light of present research, both deceased donor uterine procurement and transplantation surgeries are technically feasible; however, more experience is needed to determine the pregnancy success rate associated with this method. Thus, additional trials of deceased donor uterine transplantation should be performed in the future to continue research related to this promising concept for the treatment of absolute uterine factor infertility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.13992","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:04:16Z","timestamp":1557187456000},"page":"1458-1465","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Clinical pregnancy after deceased donor uterus transplantation: Lessons learned and future perspectives"],"prefix":"10.1111","volume":"45","author":[{"given":"Roman","family":"Chmel","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, 2nd Faculty of Medicine Charles University and Motol University Hospital  Prague Czech Republic"},{"name":"Transplantation Surgery Department Institute of Clinical and Experimental Medicine  Prague Czech 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