{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:36:46Z","timestamp":1761745006631,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Uterine leiomyosarcoma (LMS) is a rare tumor. It has not been established if these tumors arise <jats:italic>de novo<\/jats:italic> or from pre\u2010existing leiomyomas (LM). We report a case herein of LMS arising from a subserosal LM. A 47\u2010year\u2010old nulliparous woman was diagnosed with a uterine tumor measuring 30\u2009cm in diameter by pelvic magnetic resonance imaging. Serum CA\u2010125 level was 369 U\/mL, and the lactate dehydrogenase level was elevated (565\u2009IU\/L, respectively). Positron emission tomography\u2010computed tomography revealed abnormal uptake (SUV<jats:sub>max<\/jats:sub> = 25.29) of the abdominal tumor. Upon laparotomy, a large tumor with solid and cystic components was shown to arise from a subserosal LM, with invasion into the greater omentum and small intestine. Abdominal hysterectomy, bilateral salpingo\u2010oophorectomy, omentectomy and small intestine resection were performed. Macroscopic findings showed that the LMS was adherent to a subserosal LM, without continuity between the tumor and the uterus.<\/jats:p><jats:p>Our case supports the hypothesis that LMS can arise from a pre\u2010existing LM.<\/jats:p>","DOI":"10.1111\/jog.14037","type":"journal-article","created":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T09:58:02Z","timestamp":1560938282000},"page":"1944-1947","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Case of leiomyosarcoma arising from subserosal leiomyoma"],"prefix":"10.1111","volume":"45","author":[{"given":"Maiko","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-5314","authenticated-orcid":false,"given":"Soshi","family":"Kusunoki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hirayama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunari","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhisa","family":"Terao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuo","family":"Itakura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Juntendo University Faculty of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,19]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.689111"},{"key":"e_1_2_4_4_1","first-page":"84","article-title":"Leiomyosarcoma: A rare malignant transformation of a uterine leiomyoma","volume":"36","author":"Di Luigi G","year":"2015","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1014"},{"key":"e_1_2_4_6_1","first-page":"432","article-title":"Uterine leiomyoma. 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