{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:13:52Z","timestamp":1791724432961,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001104","name":"RANZCOG Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To correlate plasma and urinary soluble fms\u2010like tyrosine kinase 1 (sFlt\u20101) and placental growth factor (PIGF) in preeclampsia (PE) and fetal growth restriction (FGR) and assess the performance in detecting established disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional case\u2013control study recruited 26\u201340\u2009weeks gestation pregnancies into four clinical groups: normal pregnancy, PE, PE\u2009+\u2009FGR, and FGR. enzyme\u2010linked immunosorbent assay (ELISA) measurements of urinary and plasma sFlt\u20101 and PlGF levels were performed. Urinary levels of sFlt\u20101 and PIGF were normalized to creatinine. Spearman's rank correlation was used to assess the association between plasma and urinary levels of sFlt\u20101 and PIGF, and receiver operating characteristic graphs were used to quantify the performance of each individual marker and their ratios in predicting normal versus pathological pregnancies affected by preeclampsia and\/or FGR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant correlation between plasma PlGF and urinary PlGF (<jats:italic>r<\/jats:italic> =\u20090.718, <jats:italic>P<\/jats:italic> &lt;\u20090.001) in all groups. In the pathological groups, plasma sFlt\u20101 and urinary sFlt\u20101 as well as plasma sFlt\u20101: PIGF ratio and urinary sFlt\u20101: PlGF ratio were higher, but plasma PIGF and urinary PlGF were lower when compared to normal pregnancy. Plasma PIGF and plasma sFlt\u20101: PlGF ratio was comparable in performance to urinary PlGF and urinary sFlt\u20101: PIGF ratio for the diagnosis of preeclampsia and\/or FGR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Urinary PIGF can be used as an alternative to circulating biomarkers in preeclampsia and FGR. Plasma sFlt\u20101, PlGF and sFlt\u20101: PlGF ratio as well as urinary PIGF and sFlt\u20101: PlGF ratio can be used to differentiate between normal pregnancy and pregnancies complicated by preeclampsia and FGR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14038","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T12:43:34Z","timestamp":1567082614000},"page":"1828-1836","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Urinary placental growth factor in preeclampsia and fetal growth restriction: An alternative to circulating biomarkers?"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4871-2261","authenticated-orcid":false,"given":"Kewei","family":"Zhang","sequence":"first","affiliation":[{"name":"Westmead Institute for Maternal and Fetal Medicine  Westmead New South Wales Australia"},{"name":"The University of Sydney at Westmead Hospital  Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Zen","sequence":"additional","affiliation":[{"name":"Westmead Institute for Maternal and Fetal Medicine  Westmead New South Wales Australia"},{"name":"The University of Sydney at Westmead Hospital  Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Popovic","sequence":"additional","affiliation":[{"name":"Westmead Institute for Maternal and Fetal Medicine  Westmead New South Wales Australia"},{"name":"The University of Sydney at Westmead Hospital  Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent W.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Westmead Hospital  Westmead New South Wales Australia"},{"name":"The University of Sydney at Westmead Hospital  Westmead New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thushari I.","family":"Alahakoon","sequence":"additional","affiliation":[{"name":"Westmead Institute for Maternal and Fetal Medicine  Westmead New South Wales Australia"},{"name":"The University of Sydney at Westmead Hospital  Westmead New South Wales 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