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Pregnant women who use a substance and the consequent impacts on a newborn vary across studies and settings. We reviewed New Zealand and Australian literature to examine the short\u2010term health outcomes of newborn of substance\u2010using mothers and their demographic characteristics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five medical\/nursing databases and google scholar were searched in April 2017. Studies were considered eligible if they described outcomes of newborn of substance\u2010using mothers. Mixed Methods Appraisal Tool was used for quality assessment of candidate studies. Relevant data were extracted and analyzed using narrative synthesis. Based on data availability, a subset of studies was included in meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although findings of individual studies vary, there are some evidence that the infants born to substance\u2010using mothers were likely to have preterm birth, low birthweight, small\u2010for\u2010gestational age, low Apgar score, and admission to neo\u2010natal intensive care unit. The likelihood of adverse health outcomes was much higher for newborns of polysubstance\u2010using mothers, than newborns of mothers using a single substance. Pregnant women who use illicit substance are predominantly socially disadvantaged, in their twenties and or of Aboriginal descent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Infants of substance\u2010using mothers suffer a range of adverse health outcomes. Multidisciplinary and integrated approach of services that ensure supportive social determinants of health may result in a better outcome for newborn and positive behavioral change among mothers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14051","type":"journal-article","created":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T04:55:15Z","timestamp":1563339315000},"page":"1783-1795","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Short\u2010term health outcomes of newborn infants of substance\u2010using mothers in Australia and New Zealand: A systematic review"],"prefix":"10.1111","volume":"45","author":[{"given":"Helen T.","family":"Oni","sequence":"first","affiliation":[{"name":"Department of Public Health La Trobe University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Md Nuruzzaman","family":"Khan","sequence":"additional","affiliation":[{"name":"Research Centre for Generational Health and Ageing, School of Medicine and Public Health The University of Newcastle  Newcastle New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Abdel\u2010Latif","sequence":"additional","affiliation":[{"name":"Department of Neonatology Centenary Hospital for Women and Children, Canberra Hospital  Canberra Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Buultjens","sequence":"additional","affiliation":[{"name":"Department of Public Health La Trobe University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Mofizul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Public Health La Trobe University  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1258\/om.2010.100014"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1037\/e674312010-001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0733-8627(20)30253-4","article-title":"The impact of drug abuse and addiction on society","volume":"8","author":"Hoffman RS","year":"1990","journal-title":"Emerg Med Clin North Am"},{"key":"e_1_2_7_5_1","volume-title":"National Drug Strategy Household Survey 2016: Detailed Findings. 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