{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:37:14Z","timestamp":1792521434449,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T00:00:00Z","timestamp":1565740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2016YFC1302601"],"award-info":[{"award-number":["2016YFC1302601"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572554"],"award-info":[{"award-number":["81572554"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Subjects with germline <jats:italic>BRCA1\/2<\/jats:italic> mutations (<jats:italic>gBRCAm<\/jats:italic>) have an increased risk of developing breast cancer and ovarian cancer. At present, knowledge of <jats:italic>BRCA1\/2<\/jats:italic> mutation frequency in Chinese patients with ovarian cancer is still insufficient, and the detailed clinical information of these patients is poorly understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 547 unselected ovarian cancer patients were enrolled, and their <jats:italic>gBRCAm<\/jats:italic> status was detected. Clinical characteristics including age, personal and family history, histopathologic diagnosis, carbohydrate antigen 125 (CA\u2010125) level, ascites, Federation International of Gynecology and Obstetrics (FIGO) stage, residual lesions, platinum sensitivity, recurrence interval and survival information were collected. Accurate assessments of disease response were based on the RECIST standard or CA\u2010125 level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In 547 patients with ovarian cancer, we detected 129 (23.6%) patients with pathogenic mutations, 84 patients with <jats:italic>BRCA1<\/jats:italic> mutations (15.4%) and 45 patients with <jats:italic>BRCA2<\/jats:italic> mutations (8.2%). Twenty\u2010five novel mutations were identified, and the mutation of <jats:italic>BRCA1<\/jats:italic>, c.5470_5477del8, was the most common mutation in this study. <jats:italic>BRCA1\/2<\/jats:italic> mutations were significantly associated with age; personal and family history; FIGO stage; secondary recurrence interval; sensitivity to platinum in 1st, 2nd and 3rd line treatment; and response to doxorubicin liposomes. Patients with <jats:italic>BRCA1\/2<\/jats:italic> mutations showed significant advantages in 3\u2010 and 5\u2010year survival rates but no advantage in long\u2010term survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>BRCA1\/2<\/jats:italic> mutation prevalence in Chinese ovarian cancer patients is higher than the international rate. We recommend <jats:italic>BRCA1\/2<\/jats:italic> testing for patients with family histories and personal histories of malignancy and genetic counseling for cancer in healthy people with high\u2010risk family histories.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14090","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T13:04:29Z","timestamp":1565787869000},"page":"2267-2274","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["<i>BRCA<\/i> mutation frequency and clinical features of ovarian cancer patients: A report from a Chinese study group"],"prefix":"10.1111","volume":"45","author":[{"given":"Hualei","family":"Bu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingshui","family":"Li","sequence":"additional","affiliation":[{"name":"Gynecologic Oncology Ward 1, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqing","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Gynecology Yantai Yuhuangding Hospital of Qingdao University Medical College  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongsheng","family":"He","sequence":"additional","affiliation":[{"name":"Technical Department, Shanghai Topgen Biopharm Technology Co, Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youzhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8300-4194","authenticated-orcid":false,"given":"Beihua","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Qilu Hospital of Shandong University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3144"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10166"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt095"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24060"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1703"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353786"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000086"},{"issue":"4","key":"e_1_2_6_11_1","first-page":"e158","article-title":"Correction to Lancet Oncol 2014; 15: 856. 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