{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T03:18:25Z","timestamp":1765423105647,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A rare case of telomeric association between Y and 19 chromosomes in a 24\u2010year\u2010old patient with primary ovarian insufficiency is being reported. Clinical evaluation revealed a webbed neck, high\u2010arched palate and short stature with absence of axillary hair. Small uterus and streak gonads were noted on pelvic ultrasonography. Cytogenetic analysis showed a mosaic karyotype 46,X,tas(Y;19)(p11.3;q13.4)\/45,X with two centromeres on the derivative chromosome. Fluorescence in situ hybridization (FISH) for X and Y centromere, SRY gene and subtelomeric FISH showed that signals for SRY and heterochromatin of Y chromosome were found at the base of chromosome 19 and the subtelomere regions of 19q and Yp were intact. Multiplex polymerase chain reaction was done to check for common microdeletions in AZF region and showed no microdeletion. Due to the presence of Y chromosome, laparoscopic examination followed by gonadal histopathology was done and confirmed the presence of ovotestes. Gonadectomy was performed to avoid future risk of gonadoblastoma. Artificial reproductive techniques using donor oocytes was suggested to the couple.<\/jats:p>","DOI":"10.1111\/jog.14098","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T03:18:22Z","timestamp":1566962302000},"page":"2293-2296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Telomeric association between chromosomes Y and 19 in a mosaic Turner with primary ovarian insufficiency"],"prefix":"10.1111","volume":"45","author":[{"given":"Linda C.","family":"Barnabas","sequence":"first","affiliation":[{"name":"Center for Genetic Studies &amp; Research The Madras Medical Mission  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kundavi","family":"Shankar","sequence":"additional","affiliation":[{"name":"Institute of Reproductive Medicine &amp; Women's Health The Madras Medical Mission  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0317-2935","authenticated-orcid":false,"given":"Bibhas","family":"Kar","sequence":"additional","affiliation":[{"name":"Center for Genetic Studies &amp; Research The Madras Medical Mission  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv036"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11948.1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025437329427"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365599309181269"},{"key":"e_1_2_6_6_1","first-page":"133","article-title":"Telomeric associations","volume":"16","author":"Schwartz HS","year":"1990","journal-title":"Appl Cytogenet"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.9.e52"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13246"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30146"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-013-2028-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.4274\/jpr.35744"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/7.6.603"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.14098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14098","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.14098","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14098","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:02:06Z","timestamp":1694210526000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.14098"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,27]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/jog.14098"],"URL":"https:\/\/doi.org\/10.1111\/jog.14098","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"type":"print","value":"1341-8076"},{"type":"electronic","value":"1447-0756"}],"subject":[],"published":{"date-parts":[[2019,8,27]]},"assertion":[{"value":"2019-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}