{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:00:38Z","timestamp":1763535638935,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify potential biomarkers for tumor progression and patient outcomes in cervical squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined the expressions of CK7 and CK17 as potential markers of the squamo\u2010columnar junction, and podoplanin as a basal cell marker using surgical and biopsy samples of patients in grade 3 cervical intraepithelial neoplasia (<jats:italic>n<\/jats:italic> =\u200930), operable invasive carcinoma (OP group, <jats:italic>n<\/jats:italic> =\u200953) and inoperable invasive carcinoma before radiotherapy and\/or chemotherapy (RC group, <jats:italic>n<\/jats:italic> =\u200976).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The positive rates of CK7 and podoplanin in invasive carcinoma were significantly lower than those in grade 3 cervical intraepithelial neoplasia (<jats:italic>P<\/jats:italic> =\u20090.001, <jats:italic>P<\/jats:italic> &lt;\u20090.0001). The positive rates of CK7 and podoplanin in the RC group were significantly lower than those in the OP group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001, <jats:italic>P<\/jats:italic> = 0.04), while CK17 expression showed significantly higher positivity in the RC group than in the OP group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Negative CK7 expression showed a potential impact on overall survival in early\u2010stage patients. In the RC group, the prevalence of cases with post\u2010therapeutic residual carcinoma cells was higher in the CK7\u2010negative group than in the positive group (<jats:italic>P<\/jats:italic> =\u20090.003). We found that decreased expression of CK7 could be a prognostic factor in early\u2010stage cervical cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This result may provide strategies and suggestions for new treatment options and follow\u2010up practices in managing patients with cervical cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14108","type":"journal-article","created":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T06:15:27Z","timestamp":1568096127000},"page":"2228-2236","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Decreased cytokeratin 7 expression correlates with the progression of cervical squamous cell carcinoma and poor patient outcomes"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7151-2316","authenticated-orcid":false,"given":"Mariko","family":"Hashiguchi","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Microbiology, Faculty of Medicine Saga University  Saga Japan"},{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Microbiology, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Kai","sequence":"additional","affiliation":[{"name":"Department of Pathology Saga University Hospital  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshifumi","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Center for Comprehensive Community Medicine Saga University Faculty of Medicine  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynecology, Faculty of Medicine Saga University  Saga Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Aishima","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Microbiology, Faculty of Medicine Saga University  Saga Japan"},{"name":"Department of Pathology Saga University Hospital  Saga 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