{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:24:01Z","timestamp":1780730641985,"version":"3.54.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T00:00:00Z","timestamp":1570492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The presence of amniotic fluid sludge has been identified as a risk factor for preterm birth. We sought to validate the clinical characteristics of amniotic fluid sludge in Japanese pregnant women with preterm labor and intact membranes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study of 54 patients. The presence of amniotic fluid sludge was confirmed using transvaginal ultrasonography data during pregnancy. The following data were collected: gestational age, the presence of histologic chorioamnionitis, time from the diagnosis of threatened premature labor to delivery, oncofetal fibronectin (onfFN) levels, C\u2010reactive protein peak value levels, cervical length at the time of onset of threatened premature labor and types of neonatal complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant differences (<jats:italic>P<\/jats:italic> =\u20090.03) were observed in the age at delivery in relation to the presence of amniotic sludge: delivery occurred at 28.3\u2009\u00b1\u20094.5\u2009weeks and 31.7\u2009\u00b1\u20094.3\u2009weeks in sludge positive patients and sludge\u2010negative patients, respectively. Presence of sludge in patients diagnosed with histological chorioamnionitis at &lt;37\u2009weeks of gestation differed significantly (<jats:italic>P<\/jats:italic> =\u20090.01): sludge\u2010positive, 81.8%; sludge\u2010negative, 20.9%. Among the sludge\u2010positive patients, 100% were positive for serum onfFN (\u226550\u2009ng\/mL), whereas only 54% of sludge\u2010negative patients were positive for serum onfFN (<jats:italic>P<\/jats:italic> =\u20090.03). Presence of amniotic fluid sludge did not significantly affect neonatal complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results confirmed previous findings that amniotic fluid sludge is a self\u2010determining risk factor for preterm birth and chorioamnionitis in pregnant Japanese women.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14141","type":"journal-article","created":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T04:53:47Z","timestamp":1570596827000},"page":"87-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Association of amniotic fluid sludge with preterm labor and histologic chorioamnionitis in pregnant Japanese women with intact membranes: A retrospective 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