{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T10:12:22Z","timestamp":1694167942080},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Methotrexate (MTX) treatment at a dose of 50\u2009mg\/m<jats:sup>2<\/jats:sup> of body surface area (BSA) is an effective and widely used treatment method in ectopic pregnancy. However, there is a limited number of studies investigating lower MTX doses. In this study, we aimed to investigate the efficacy of lower MTX doses in the treatment of ectopic pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included a total of 112 patients who were hospitalized due to ectopic pregnancy and administered single\u2010dose MTX. The patients were divided into three groups according to the dose given as 22\u201340\u2009mg\/m<jats:sup>2<\/jats:sup> of BSA (<jats:italic>n<\/jats:italic> =\u200917), 41\u201349\u2009mg\/m<jats:sup>2<\/jats:sup> of BSA (<jats:italic>n<\/jats:italic> =\u200981) and\u2009\u2265\u200950\u2009mg\/m<jats:sup>2<\/jats:sup> of BSA (<jats:italic>n<\/jats:italic> =\u200914). Data including demographic characteristics of the patients, previous history of ectopic pregnancy, previous gynecological surgeries, the use of <jats:italic>in vitro<\/jats:italic> fertilization techniques, ultrasonographic findings, beta\u2010human chorionic gonadotropin hormone (\u03b2\u2010hCG) levels, pre\u2010treatment endometrial sampling, MTX doses applied, and the need for a surgical intervention during follow\u2010up were retrieved from the hospital records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the patients, 16.96% (<jats:italic>n<\/jats:italic> =\u200919) were operated at the end of treatment, irrespective of the pre\u2010treatment \u03b2\u2010hCG levels with a success rate of 83% (<jats:italic>n<\/jats:italic> =\u200993). Fourteen (12.5%) of the patients received the second dose of MTX. The overall success rate was 89.2% in patients with a \u03b2\u2010hCG level of \u22645000 mIU\/mL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that lower MTX doses than 50\u2009mg\/m<jats:sup>2<\/jats:sup>, which has been considered standard treatment and widely used in the treatment of ectopic pregnancy for nearly three decades, are effective with similar success rates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14167","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T12:40:57Z","timestamp":1578660057000},"page":"286-292","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative study of low\u2010dose versus standard single\u2010dose methotrexate: A novel approach for medical treatment of ectopic pregnancy"],"prefix":"10.1111","volume":"46","author":[{"given":"G\u00fcltekin 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