{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:47:39Z","timestamp":1791406059461,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effectiveness of adjuvant treatment for morcellated, uterus\u2010confined leiomyosarcoma in a multicenter setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified patients with International Federation of Gynecology and Obstetrics stage I uterine leiomyosarcoma primarily treated with surgery between 2003 and 2016. Among them, patients who underwent one of the following morcellation methods were included: (i) power morcellation; (ii) intracorporeal morcellation using scalpels or electrocautery; and (iii) vaginal morcellation. Patients' survival outcomes were compared according to the implementation of adjuvant treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 13 institutions, 55 patients were included; 31 for adjuvant treatment group and 24 for surgery only group. The clinicopathological characteristics including the mass size, morcellation methods, extent of surgery, and mitotic count were similar between the groups. In the adjuvant treatment group, 67.7%, 19.4% and 12.9% of patients received chemotherapy, chemoradiation and radiation, respectively. After a median follow\u2010up of 50.5\u2009months, the adjuvant treatment and surgery only groups showed similar overall survival (5\u2010year rate, 92.0% vs 90.4%; <jats:italic>P<\/jats:italic> = 0.959). No significant difference in progression\u2010free survival was observed between the two groups (3\u2010year rate, 46.1% vs 78.2%; <jats:italic>P<\/jats:italic> = 0.069). On multivariate analyses, adjuvant treatment did not affect progression\u2010free survival (adjusted HR, 2.138; 95% CI, 0.550\u20138.305; <jats:italic>P<\/jats:italic> = 0.273). The adjuvant treatment group showed a trend towards more common distant metastasis, compared to the surgery only group (25.8% vs 4.2%; <jats:italic>P<\/jats:italic> = 0.062). The incidences of pelvic, retroperitoneal, and abdominal recurrences were not different between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite its frequent use in clinical practice, adjuvant treatment did not improve the survival outcomes of patients with morcellated, International Federation of Gynecology and Obstetrics stage I uterine leiomyosarcoma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14171","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T08:42:36Z","timestamp":1575880956000},"page":"337-346","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effectiveness of adjuvant treatment for morcellated, International Federation of Gynecology and Obstetrics stage I uterine leiomyosarcoma: A Korean multicenter study"],"prefix":"10.1111","volume":"46","author":[{"given":"Se Ik","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chel Hun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kidong","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Seoul National University Bundang Hospital  Seongnam Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deok Ho","family":"Hong","sequence":"additional","affiliation":[{"name":"Dongtan Jeil Hospital  Hwaseong Republic of 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National University Chilgok Hospital  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So\u2010Jin","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Keimyung University School of Medicine  Daegu Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Il","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology Dongnam Institute of Radiological and Medical Sciences  Busan Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Ewha Womans University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Gachon University Gil Medical Center Gachon University College of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Korea University Anam Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hwa","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Korea University Guro Hospital Korea University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Yun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science Yonsei University College of Medicine  Seoul Republic of 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