{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T20:37:14Z","timestamp":1694119034311},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T00:00:00Z","timestamp":1578614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the outcome of intracytoplasmic sperm injection (ICSI) pregnancies complicated by spontaneous loss of a dichorionic co\u2010twin with that of singleton ICSI pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group included dichorionic ICSI pregnancies with co\u2010twin loss (<jats:italic>n<\/jats:italic> = 33) and the control group included ICSI pregnancies with a singleton from the beginning (<jats:italic>n<\/jats:italic> = 327). Primary outcome measures were obstetric complications, including preterm delivery, newborn small for gestational age, gestational diabetes, gestational hypertensive disorders and abruptio placenta; admission to neonatal intensive care unit (NICU) and perinatal mortality observed in the study and control groups. Statistical analysis was performed using <jats:sc>spss<\/jats:sc> for Windows, version 22.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the study group, there were 26 cases of first trimester (early) and 7 cases of second or third trimester (late) co\u2010twin losses. Mean gestational age at delivery and mean birth weight were significantly lower in the whole study group compared to control (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Preterm delivery and NICU admission rates were significantly higher in the whole study group, compared to control (39.3% vs 14.6% and 36.36% vs 11.69% respectively, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), but did not show significant difference between early loss subgroup and control (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Preterm delivery rate was significantly higher in the late loss subgroup compared to the early loss subgroup (85.71% vs 26.92% <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Loss of a co\u2010twin in dichorionic ICSI pregnancies is associated with increased risk of preterm birth. This risk is significantly higher in cases with late loss compared to the early loss cases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14177","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T12:43:06Z","timestamp":1578660186000},"page":"445-450","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Outcome of ICSI pregnancies with spontaneous loss of a co\u2010twin compared with singleton ICSI pregnancies: Single center experience"],"prefix":"10.1111","volume":"46","author":[{"given":"Nihal \u015e.","family":"Uysal","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology Ba\u015fkent University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7a\u011fr\u0131","family":"G\u00fcl\u00fcmser","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology Ba\u015fkent University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filiz F.","family":"Bilgin Yan\u0131k","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Division of Perinatology Ba\u015fkent University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6\u011f\u015fen","family":"\u00d6nalan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Inferitility and Assisted Reproduction Unit Ba\u015fkent University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hulusi B.","family":"Zeynelo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Inferitility and Assisted Reproduction Unit Ba\u015fkent University Faculty of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,10]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"603","article-title":"Effect of spontaneous pregnancy reduction on obstetric outcome","volume":"50","author":"Steinkampf MP","year":"2005","journal-title":"J Reprod Med"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/4.2.177"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2002.118915"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei142"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.076"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.5603\/GP.a2018.0006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.02.009"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000114989.84822.51"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(15)30685-X"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.18930"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dem225"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.06.022"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.01027.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2011.640369"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2005.00637.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767050600965882"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.01.044"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dms010"},{"key":"e_1_2_6_20_1","unstructured":"CasanovaC BellverJ GarridoN LaraC PellicerA SerraV. 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