{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T20:14:54Z","timestamp":1785528894020,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T00:00:00Z","timestamp":1580342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key Research and Development Project of AnHui Province","award":["1701a0802171"],"award-info":[{"award-number":["1701a0802171"]}]},{"name":"HeFei Municipal Health Planning Commission","award":["hwk2017yb009"],"award-info":[{"award-number":["hwk2017yb009"]}]},{"name":"Key Talents of Maternal and Child Health in Jiangsu Province","award":["FRC201715"],"award-info":[{"award-number":["FRC201715"]}]},{"name":"Science Technology Innovation Project of Suzhou","award":["SS201702"],"award-info":[{"award-number":["SS201702"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To explore the clinical effect of endometrial injury (EI) on the third day of the menstrual cycle before frozen\u2013thawed embryo transfer (frozen\u2013thawed ET) on patients experienced two or more implantation failures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A total of 200 patients who suffered at least two failed hormone\u2010replacement therapies and frozen\u2013thawed ET were randomly divided into two groups: EI group and control group (\n                      <jats:italic>n<\/jats:italic>\n                      = 100 in each group). Patients in the EI group received local EI with a Pipelle catheter on the third day of the menstrual cycle before frozen\u2013thawed ET. Primary outcomes were live birth, clinical pregnancy and implantation rates. Secondary outcomes were biochemical, multiple and ectopic pregnancy rates and abortion rates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The rate of live birth in EI group (51.00%) was significantly higher than that of control group (36.00%) (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.032). Clinical pregnancy and implantation rates in EI group were significantly higher comparing to control group (64.00% vs 48.00%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.023 and 46.74% vs 30.11%,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.001). The rate of multiple pregnancy in EI group (37.50%) was significantly higher than that of control group (18.75%) (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.031). No significant difference in ectopic pregnancy rate and abortion rate was observed between EI group and control group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Applying EI to patients experienced two or more implantation failures on the third day of the menstrual cycle before frozen\u2013thawed ET can improve clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jog.14193","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T20:11:37Z","timestamp":1580415097000},"page":"451-458","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of endometrial injury during menstruation on clinical outcomes in frozen\u2013thawed embryo transfer cycles: A randomized control trial"],"prefix":"10.1111","volume":"46","author":[{"given":"Zhixia","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The Second Affiliated Hospital of Soochow University  Suzhou China"},{"name":"Reproductive Medicine Center, Maternity and Child Health Hospital of Anhui Province, The Maternal and Child Health Clinical College Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyun","family":"Hong","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Maternity and Child Health Hospital of Anhui Province, The Maternal and Child Health Clinical College Anhui Medical University  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"He","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Center, Maternity and Child Health Hospital of Anhui Province, The Maternal and Child Health Clinical College Anhui 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