{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T14:56:45Z","timestamp":1781794605100,"version":"3.54.5"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study is to evaluate whether unacceptable bleeding among the etonogestrel implant user could be better alleviated using combined oral contraceptive pills (COCP) or nonsteroidal anti\u2010inflammation drugs (NSAID).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective randomized study for evaluation of 84 etonogestrel implant (Implanon) users with prolonged or frequent bleeding. They were assigned to either receiving a COCP containing 20\u2009mcg ethinyl estradiol\/150\u2009mg desogestrel for two continuous cycle or NSAID; mefenamic acid 500\u2009mg TDS for 5\u2009days, 21\u2009days apart for two cycles. Bleeding pattern during the treatment was recorded and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 32 women (76.2%) in COCP group and 15 women (35.7%) in NSAID group stop bleeding within 7\u2009days after the initiation of treatment which was statistically significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). The mean duration of bleeding and spotting days in women treated with COCP was significantly lesser compared to NSAID group (7.29\u2009\u00b1\u20093.16 vs 10.57\u2009\u00b1\u20094.14\u2009days (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that COCP is more efficient compared to NSAID in managing bleeding irregularities among etonogestrel implant users.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14195","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T01:24:07Z","timestamp":1579569847000},"page":"479-484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Management of bleeding irregularities among etonogestrel implant users: Is combined oral contraceptives pills or nonsteroidal anti\u2010inflammatory drugs the better option?"],"prefix":"10.1111","volume":"46","author":[{"given":"Siti N.","family":"Upawi","sequence":"first","affiliation":[{"name":"Obstetrics &amp; Gynaecology Department Shah Alam Hospital  Shah Alam Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd F.","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynaecology Department UKM Medical Center  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad A.","family":"Abu","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynaecology Department UKM Medical Center  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2735-3274","authenticated-orcid":false,"given":"Shuhaila","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Obstetrics &amp; Gynaecology Department UKM Medical Center  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.02.140"},{"issue":"3","key":"e_1_2_7_3_1","first-page":"CD001326","article-title":"Subdermal implantable contraceptives versus other forms of reversible contraceptives or other implants as effective methods of preventing pregnancy","author":"Power J","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/13625180801959931"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70326-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13625187.2016.1210122"},{"key":"e_1_2_7_7_1","first-page":"64","article-title":"The effect of mefenamic acid on controlling irregular uterine bleeding second to Implanon use","volume":"87","author":"Phaliwong P","year":"2004","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002810"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/11.suppl_2.109"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000974"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138341"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0010-7824(99)00059-1"},{"key":"e_1_2_7_13_1","first-page":"301","article-title":"Efficacy of celecoxib on controlling irregular uterine bleeding secondary to Jadelle use","volume":"92","author":"Buasang K","year":"2009","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2015.07.004"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjog.14195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14195","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.14195","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14195","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:40:55Z","timestamp":1694050855000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.14195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,20]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/jog.14195"],"URL":"https:\/\/doi.org\/10.1111\/jog.14195","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"value":"1341-8076","type":"print"},{"value":"1447-0756","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,20]]},"assertion":[{"value":"2019-06-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}