{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:05:47Z","timestamp":1765713947704,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T00:00:00Z","timestamp":1579392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the clinical management to withhold treatment for preterm labor in symptomatic women with an intermediate cervical length and negative fetal fibronectin (fFN) testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was performed in a tertiary care teaching hospital in the Netherlands. Pregnant women with a gestational age between 23<jats:sup>+5<\/jats:sup> to 34<jats:sup>+0<\/jats:sup> weeks, with the presence of regular uterine contractions accompanied by a cervical length between 15 and 30\u2009mm and intact membranes, who underwent fFN testing were included to obtain the diagnostic value of fFN testing for preterm delivery within 7\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fetal fibronectin testing has an extremely high negative predictive value (100%) and sensitivity (100%) for delivery within 7\u2009days, in singleton and multiple pregnancies. However, specificity (64%) and positive predictive value (10%) of fFN testing in singleton pregnancies are low. Blood present on the fFN sample does not affect the reliability of the fFN test; the negative predictive value remains 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women with symptoms of early preterm labor, intact membranes, a cervical length between 15 and 30\u2009mm and negative fFN testing do not deliver within 7\u2009days. Administration of corticosteroids and tocolytics can safely be withhold. Furthermore, blood on the fFN sample does not change the reliability of the fFN test.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14201","type":"journal-article","created":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T23:14:28Z","timestamp":1579475668000},"page":"405-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The diagnostic value of fetal fibronectin testing in clinical practice"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5290-6080","authenticated-orcid":false,"given":"Lisa G. H.","family":"Cornelissen","sequence":"first","affiliation":[{"name":"Department of Gynecology Maxima Medical Center  Veldhoven Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noortje H. M.","family":"van Oostrum","sequence":"additional","affiliation":[{"name":"Department of Gynecology Maxima Medical Center  Veldhoven Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisy A. A.","family":"van der Woude","sequence":"additional","affiliation":[{"name":"Department of Gynecology Maxima Medical Center  Veldhoven Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christel","family":"Rolf","sequence":"additional","affiliation":[{"name":"Department of Gynecology Maxima Medical Center  Veldhoven Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina M.","family":"Porath","sequence":"additional","affiliation":[{"name":"Department of Gynecology Maxima Medical Center  Veldhoven Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Guid","family":"Oei","sequence":"additional","affiliation":[{"name":"Department of Gynecology Maxima Medical Center  Veldhoven Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith O. E. H.","family":"van Laar","sequence":"additional","affiliation":[{"name":"Department of Gynecology Maxima Medical Center  Veldhoven Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60820-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60560-1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2010.09.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"issue":"3","key":"e_1_2_7_7_1","first-page":"CD004454","article-title":"Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth","volume":"3","author":"Roberts D","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2016.06.001"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001711"},{"key":"e_1_2_7_10_1","article-title":"Physiology of normal labor and delivery: Part I and II","author":"Kochenour NK","year":"1997","journal-title":"Hum Reprod Clin Pathol Pharmacol Correlat"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2017.08.002"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13752"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.29252\/ijrm.15.11.697"},{"key":"e_1_2_7_14_1","first-page":"63","article-title":"What is the risk of preterm delivery after arrested preterm labor?","volume":"32","author":"Wilms FF","year":"2015","journal-title":"Am J Perinatol"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2013.06.029"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.017"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.17481"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000229"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70612-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000635"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.5297"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2018.06.019"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.05.074"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1570379"}],"container-title":["Journal of Obstetrics and Gynaecology Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14201","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jog.14201","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jog.14201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:41:31Z","timestamp":1694050891000},"score":1,"resource":{"primary":{"URL":"https:\/\/obgyn.onlinelibrary.wiley.com\/doi\/10.1111\/jog.14201"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,19]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/jog.14201"],"URL":"https:\/\/doi.org\/10.1111\/jog.14201","archive":["Portico"],"relation":{},"ISSN":["1341-8076","1447-0756"],"issn-type":[{"type":"print","value":"1341-8076"},{"type":"electronic","value":"1447-0756"}],"subject":[],"published":{"date-parts":[[2020,1,19]]},"assertion":[{"value":"2019-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}