{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T06:50:56Z","timestamp":1771051856915,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T00:00:00Z","timestamp":1583798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This trial was conducted to determine the efficacy of umbilical vein injection of 400 versus 800\u2009\u03bcg misoprostol to deliver retained placenta and to compare both regimens regarding the time of placental delivery and amount of vaginal blood loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A double\u2010blind, multicenter randomized clinical trial was undertaken in four teaching hospitals in the North of Iraq and Al\u2010Azhar University Hospital in Egypt, from March 2016 to May 2019. Group I (274 women) received 400\u2009\u03bcg misoprostol and group II (249 women) received 800\u2009\u03bcg misoprostol. Data regarding the time of placental separation and amount of vaginal blood loss were analyzed and proportions were compared between groups using Chi\u2010squared test. Mean values were compared using the Student's <jats:italic>t<\/jats:italic>\u2010test. The Mann\u2013Whitney test was used to determine the median of vaginal blood loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportion of placental separation was 84.3% among women in group I and 86.7% of women in group II. The mean time of placental separation was 18.86\u2009\u00b1\u2009234.2 and 17.86\u2009\u00b1\u2009213.09\u2009min in groups I and II, respectively (<jats:italic>P<\/jats:italic> &lt;\u20090.05).The mean hemoglobin levels on admission and 24\u2009h after placental deliveries were significantly higher in group I than group II.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intra\u2010umbilical injection of 400 and 800\u2009\u03bcg misoprostol were both safe and effective methods for delivery of retained placenta.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14232","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T05:44:29Z","timestamp":1583905469000},"page":"727-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Umbilical vein injection of 400 versus 800\u2009\u03bcg misoprostol for the treatment of retained placenta: A multicenter, randomized double\u2010blind controlled trial"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1259-0338","authenticated-orcid":false,"given":"Shahla K.","family":"Alalaf","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Hawler Medical University, College of Medicine  Erbil City Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namir G.","family":"Al Tawil","sequence":"additional","affiliation":[{"name":"Department of Community Medicine Hawler Medical University, College of Medicine  Erbil City Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariana K.","family":"Jawad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kurdistan Board for Medical Specialties  Erbil City Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam B.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Sulaimani, College of Medicine  Sulaimani City Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bahar Q.","family":"Muhamad","sequence":"additional","affiliation":[{"name":"Hawler Ministry of Health, Directorate of Health Maternity Teaching Hospital  Erbil City Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khansa H.","family":"Abdul Rahman","sequence":"additional","affiliation":[{"name":"Hawler Ministry of Health, Directorate of Health Maternity Teaching Hospital  Erbil City Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sileem A.","family":"Sileem","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine for Boys Al\u2010Azhar University  Assuit City Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinan N.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of obstetrics and Gynecology University of Duhok, College of Medicine  Duhok City Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalida M.","family":"Ameen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Kirkuk, Kirkuk Medical College  Kirkuk City Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samira A.","family":"Mustafa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Hawler Medical University, College of Medicine  Erbil City Iraq"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AbdulKader A.","family":"Bawadikji","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science University Sains Malaysia  Penang Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,10]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"CD010312","article-title":"Prostaglandins for management of retained placenta","volume":"5","author":"Grillo\u2010Ardila CF","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2008.07.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2017.1379071"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0029-7844(95)00327-N"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340601088570"},{"key":"e_1_2_7_7_1","unstructured":"World Health Organization. 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