{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T04:53:07Z","timestamp":1783399987770,"version":"3.54.6"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T00:00:00Z","timestamp":1586649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Key R&D Program of China","award":["2017YFC1001403"],"award-info":[{"award-number":["2017YFC1001403"]}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31671199"],"award-info":[{"award-number":["31671199"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31871512"],"award-info":[{"award-number":["31871512"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Shanghai Commission of Science and Technology","award":["17DZ2271100"],"award-info":[{"award-number":["17DZ2271100"]}]}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare early\u2010onset pre\u2010eclampsia (EOPE) and late\u2010onset pre\u2010eclampsia (LOPE) and provide insight into the pathophysiology of pre\u2010eclampsia (PE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our recent work compared the transcriptomics in decidua of EOPE, LOPE and normal pregnancies (NP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found there are a significant number of genes uniquely expressed in the decidua of EOPE and LOPE comparing with NP. Moreover, EOPE and LOPE have their distinct profiles. Unique EOPE\u2010associated genes were mainly involved in apoptosis related pathways such as \u2018apoptosis\u2019 and \u2018Ras signaling pathway\u2019. <jats:italic>PIK3CB<\/jats:italic> and BCL\u20102 are the core regulatory genes in EOPE decidua, their abnormal expression caused decidual abnormal apoptosis which is relevant to the pathogenesis of EOPE. Whereas, LOPE is a more complicated entity which has more special LOPE\u2010associated genes involved in decidua differentiation, especially in \u2018gap junction pathway\u2019, \u2018vascular smooth muscle contraction\u2019 and \u2018long\u2010term depression\u2019. <jats:italic>PIK3CB<\/jats:italic>, <jats:italic>FLT1<\/jats:italic>, <jats:italic>CBLC<\/jats:italic> and <jats:italic>ITGA7<\/jats:italic> are the core regulatory genes differentially expressed in EOPE decidua comparing with LOPE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In brief, the different decidual transcriptomics of EOPE and LOPE may correlate with their different etiology. These findings highlight the complex pathophysiology of PE and provide potential targets for a new treatment strategy in patients with PE.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14257","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T06:50:35Z","timestamp":1586760635000},"page":"1055-1066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Comparison of the transcriptional profile in the decidua of early\u2010onset and late\u2010onset pre\u2010eclampsia"],"prefix":"10.1111","volume":"46","author":[{"given":"Jing","family":"Tong","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University  Shanghai China"},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics  Shanghai 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