{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T22:03:18Z","timestamp":1770415398833,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["obgyn.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Obstet and Gynaecol"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To demonstrate the effect of the Syrian refugee population on the prevalence of congenital TORCH (Toxoplasmosis, Other [syphilis, varicella\u2010zoster, parvovirus B19], Rubella, Cytomegalovirus [CMV] and Herpes) infections and to evaluate the cost\u2010effectiveness of population\u2010based TORCH screening during pregnancy in Turkey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pregnant women (<jats:italic>n<\/jats:italic> = 9754) were enrolled. Ultrasonographic findings, immunoglobulin (Ig)M and IgG seropositivity, avidity, amniocentesis and DNA\u2010polymerase chain reaction (PCR) results were compared. Costs were calculated based on invoice amounts from the Health Applications Communique pricing system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of TORCH seropositivity in Turkey was not significantly different between all regions (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Overall, 1333 (13.67%) pregnant Syrian refugees were included in the study. Acute CMV, rubella and <jats:italic>Toxoplasma gondii<\/jats:italic> infections (according to low IgG avidity in IgM positive patients) were detected in 17.82%, 21.53% and 14.07% of women, respectively. Twenty\u2010four women underwent an amniocentesis procedure and nine of them had positive DNA\u2010PCR and reverse transcription\u2010PCR results. All women with positive results opted to terminate the pregnancy. There was no statistical difference among groups according to the rate of low IgG avidity in IgM\u2010positive patients and termination rates for <jats:italic>T. gondii<\/jats:italic>, rubella and CMV (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Total cost for screening the entire study population was presented in US dollars (USD). A total of 71\u2009529 and prenatal diagnosis with positive invasive test results were obtained in nine women: toxoplasmosis in four, CMV in three and rubella in two women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Population\u2010based screening for prenatal TORCH infections is not cost\u2010effective in Turkey. Syrian refugees have a limited effect on the increasing prevalence of congenital TORCH infections.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jog.14273","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T10:53:33Z","timestamp":1588071213000},"page":"1017-1024","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of Syrian refugees on congenital <scp>TORCH<\/scp> infections screening in Turkey"],"prefix":"10.1111","volume":"46","author":[{"given":"Bora","family":"\u00c7o\u015fkun","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Yuksek Ihtisas University School of Medicine Ankara Liv Hospital  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7a\u011fr\u0131","family":"G\u00fcl\u00fcmser","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Health Science School of 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